Vertex Pharmaceuticals Inc (US) Posted September 8, 2026

Senior Principal, Source to Pay Technology

Boston, United States Full time
Procurement Principal
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Vertex Pharmaceuticals Inc (US) is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

Job Description

General Summary:

The Senior Principal, Source to Pay Technology will provide technical expertise, delivery, and support for Source-to-Pay AI-powered technologies. This role will focus on the implementation and subsequent maintenance of Source to Pay Orchestration solutions and AI capabilities. This role will partner with business leadership to identify and prioritize opportunities to improve business processes with innovative technology and data, gathering and refining requirements, determining options for solution design, delivering enhancements, supporting integrations, and contributing to technology projects and initiatives.

Key Duties and Responsibilities:

Serve as a trusted advisor for business stakeholders on Source to Pay technology and AI solutions to support and enable the business goals and objectives

Collaborate with business stakeholders to understand their current and future state strategy, needs, and requirements from a global perspective

Implement AI capabilities in the Source to Pay space while meeting compliance, legal, and ethical standards, including data privacy and regulatory requirements

Proactively offer innovative technologies and solution ideas, and potential business process improvements in pursuit of driving efficiencies and meeting business needs

Facilitate workshops and discussions to collect and document user stories / requirements

Develop and document functional and technical aspects for integrations with upstream and downstream platforms

Design, perform and document system configurations within in-scope platforms and applications

Contribute to the creation and documentation of testing strategies and execution plans

Work with offshore team members and peers for platform support and technical development of enhancements and projects

Manage relationships with strategic software vendors and managed service providers (as needed)

Work closely with Privacy, DTE Compliance, and Internal Audit to ensure compliance with all appropriate regulations, data integrity policies, and Vertex’s system lifecycle and change management processes

Knowledge and Skills:

Experience with Source to Pay technologies (e.g., Contract Lifecycle Management platform (Icertis), Third-Party Risk Management platform (ProcessUnity), Electronic Signature platform (Docusign), Procure-to-Pay platform (Coupa), and Source to Pay Orchestration tools)

In-depth knowledge and hands-on experience implementing AI/ML technologies

Demonstrated ability to translate business challenges into AI-driven solutions with measurable outcomes

Functional and technical expertise with application configurations, integrations, and documentation

Demonstrated ability to understand, analyze, and document complex business processes, translate business needs and functional requirements into technical or process-driven solutions

Self-directed individual who is able to work independently and collaboratively in a matrixed team environment

Experience in program and project management, demand management, resource management and system lifecycle management

Results-oriented individual with a proven track record of on-time project delivery for large, complex projects with global stakeholders

Exceptional analytical, quantitative, problem-solving, and prioritization skills

In-depth experience in design, development, and deployment of technology solutions using agile software development practices and dev/ops model

Very strong written and verbal communication skills and ability to present in a clear and concise manner to various technical and non-technical audiences

Demonstrated ability to solve complex business problems by collaborating across organizational boundaries

Education and Experience:

Bachelor's degree in technology discipline or equivalent

8+ years of work experience with relevant business systems in the Life Sciences industry, or the equivalent combination of education and experience

Experience working with implementation partners as well as managed services providers and/or offshore teams

Preferred experience with ZipHQ

#LI-HYBRID

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$177,600 - $266,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

1.    Hybrid: work remotely up to two days per week; or select

2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Job details

Seniority
Principal
Function
Procurement
Therapeutic area
Not listed
Location
Boston, United States
Employment type
Full time

How this role compares

Computed from every other active Procurement role in our database, not just this employer's listings.

We currently track 39 comparable Principal Procurement roles across 16 biopharma companies.

39Comparable roles tracked
32Currently active
16Companies hiring similar roles
16Countries represented

Salary context

12 of 39 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject $177,600/yr – $266,400/yr
Lowest disclosed · Senior Specialist, R&D Procurement · AbbVie $84,500/yr – $162,000/yr
Peer group range $123,250 – $244,150 (median $193,938)

Where these roles are based

Top locations among the 39 comparable roles

United States18
Netherlands3
United Kingdom2
Philippines2
France2
China1

+ 10 more countries

Seniority mix

39 of 39 peers have a known seniority level

Director20
Senior19

Therapeutic area mix

0 of 39 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

No peers with a known therapeutic area yet.

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

50%similar
Regeneron Pharmaceuticals, Inc (USA) Tarrytown, United States Senior
Same function Adjacent seniority Same country
50%similar
UCB Atlanta, Georgia, United States Director
Same function Adjacent seniority Same country
50%similar
UCB Atlanta, Georgia, United States Director
Same function Adjacent seniority Same country
50%similar
Teva Pharmaceuticals Parsippany, United States Director
Same function Adjacent seniority Same country
50%similar
Teva Pharmaceuticals Parsippany, United States Director
Same function Adjacent seniority Same country
50%similar
GlaxoSmithKline LLC Philadelphia, United States Director
Same function Adjacent seniority Same country

Notify me about similar jobs

Get an email when we spot other openings like this one – same job function, comparable seniority, roles you'd actually want to see.

Or follow a whole field: get every new Procurement job in the United States, and choose locations and companies.

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

50%
Sr Mgr Global Procurement- Lab Consumables
Regeneron Pharmaceuticals, Inc (USA) · Tarrytown, United States · Senior
Function Therapeutic area Adjacent seniority Country
50%
Director Global Category Manager LCO/Sterile
Teva Pharmaceuticals · Parsippany, United States · Director
Function Therapeutic area Adjacent seniority Country
50%
Director Global Procurement- Training and Development
Regeneron Pharmaceuticals, Inc (USA) · Sleepy Hollow, United States · Director
Function Therapeutic area Adjacent seniority Country
50%
Senior Analyst, Vendor Management
AbbVie · North Chicago, IL · Senior
Function Therapeutic area Adjacent seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.