Senior Scientist, siRNA Screening Automation and Molecular Analytics
About this opportunity
Company Description
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.
Job Description
AbbVie’s Biotherapeutic and Genetic Medicine (BGM) department is seeking a highly motivated Senior Scientist to support the development and operation of a high-throughput siRNA screening platform. This role will focus on automation-enabled screening workflows and data analysis. The successful candidate will work closely with platform and program teams to build robust, scalable workflows that accelerate siRNA lead discovery and optimization across multiple therapeutic areas.
Responsibilities
Lead execution of high-throughput siRNA screening workflows using automated liquid-handling and other laboratory automation systems.
Develop, optimize, and troubleshoot automated methods for sample preparation workflows, including RNA extraction, RT-qPCR, and RNA-seq library preparation.
Design and execute experiments to evaluate siRNA activity, potency, and selectivity using molecular biology assay platforms.
Establish and maintain data analysis workflows for screening datasets, including assay QC, normalization, hit assessment, and interpretation of experimental results.
Drive development and implementation of next-generation sequencing (NGS)-based strategies using automation for gene expression profiling.
Partner with different groups, cross-functional scientists and bioinformatics, to support analysis and interpretation of large screening and sequencing datasets.
Contribute to the improvement, standardization, and documentation of screening workflows, assay protocols, and automation procedures.
Identify technical issues proactively and implement solutions to improve assay robustness, throughput, and reproducibility.
Present results clearly to project teams and platform leadership, and contribute to scientific discussions, experimental planning, and strategy.
Mentor junior scientists or research associates as needed and contribute to a collaborative, high-performing laboratory environment.
Qualifications
BS, MS, or PhD in Molecular Biology, Genomics, Bioinformatics, Bioengineering, or a related discipline with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
Strong hands-on experience with laboratory automation, high-throughput screening workflows, and coding for automation systems.
Deep experience with RNA extraction and RT-qPCR assay development, execution, and troubleshooting.
Familiarity with NGS workflows for library construction and gene expression profiling, including integration of automation with NGS library preparation or other downstream molecular workflows.
Experience with siRNA screening, oligonucleotide therapeutics, or RNA biology strongly preferred.
Familiarity with scripting, data processing tools, or bioinformatics collaboration models.
Prior experience supporting platform buildout in a matrixed drug discovery environment.
Strong organizational skills and attention to detail, with ability to manage multiple priorities in a fast-paced environment.
Excellent communication skills and demonstrated ability to work effectively in cross-functional teams.
Position will be filled at level commensurate with extent of education, experience, and accomplishment - Senior Scientist I or Senior Scientist II
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
This job may be eligible to participate in our long-term incentive plan.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
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Job details
How this role compares
Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.
We currently track 528 comparable Senior Manufacturing & CMC roles across 71 biopharma companies.
Salary context
226 of 528 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 528 comparable roles
+ 20 more countries
Seniority mix
528 of 528 peers have a known seniority level
Therapeutic area mix
0 of 528 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
No peers with a known therapeutic area yet.
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
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How we calculate "similar"
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Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.