Principal Research Scientist I - Biologics Analytical Research and Development, CMC Biologics Development
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Company Description
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.
Job Description
AbbVie Biologics Analytical Research & Development (Biologics Analytical R&D) is a global analytical sciences organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative therapeutic biologic medicines and spans from the selection of Discovery candidate molecules through the transition of analytical methods and testing to commercial labs to support product launch. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Biologics Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies.
The biologics characterization group develops state-of-the-art analytical techniques for in-depth characterization of therapeutic proteins and other novel biologic molecules using advanced, combined analytical techniques. We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates.
Responsibilities:
Act as a subject matter expert in BioARD, lead phase-appropriate analytical development strategies for biologics characterization including ADC, PDC, AOC, fusion proteins, multi-specific antibodies, and other novel modalities.
Design and execute the buildout of biotherapeutics extended characterization methods, to facilitate in-process analytics, batch release/stability, RS qualification, and comparability study.
Make lab-based, data-driven, and phase-appropriate contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones.
Represent key area function in cross-functional project teams, provide hands-on analytical support, technical oversight to portfolios.
Collaborate and integrate scientific objectives associated with development of new/improved products or technology; contribute to scientific exchange and publications.
Author, review lab notebook, analytical report, and analytical sections of regulatory filings. Primary author of external publications, presentations, and patents. Present at leading scientific conferences.
May mentor/supervise a team of one or more, guide and evaluate the performance of those individuals; is accountable for the effective performance of the team/individuals.
Qualifications
BS or equivalent education with 14+ years of experience; MS or equivalent education with 12+ years of experience; PhD in scientific discipline (e.g., Analytical Chemistry, Biochemistry, or Biology) with typically 6+ years of industry experience, is required.
Demonstrated proficiency and substantial hands-on experience in mass spectrometry-based characterization of biologics, including intact/subunit analysis, peptide mapping, disulfide bond mapping, etc., as well as hands-on experience in mass spec data processing and interpretation using various MS software platforms.
Strong working knowledge and familiarity with separation-based analytical techniques, including SEC, HIC, HILIC, RPLC, IEX, CE, icIEF, etc.
Knowledge in key analytical CMC areas, such as risk-based analytical development and method validation, CQAs assessment, reference standard qualification, comparability study.
Familiarity with biophysical assays, or binding and functional assays are plus.
Working knowledge of lab automation, good written and oral communication skills, time management skills.
Ability to work independently and collaboratively across functions.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Job details
How this role compares
Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.
We currently track 634 comparable Principal Manufacturing & CMC roles across 88 biopharma companies.
Salary context
228 of 634 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 634 comparable roles
+ 23 more countries
Seniority mix
634 of 634 peers have a known seniority level
Therapeutic area mix
6 of 634 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
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How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.