AstraZeneca Posted October 7, 2026

Medical Affairs Director, US Rare Nephrology

Boston, Massachusetts, United States of America Full time
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AstraZeneca is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

In collaboration with US and global medical and cross-functional colleagues, the Medical Director will lead the development and implementation of the aHUS strategic medical plan for US Medical Affairs, providing medical leadership, insights, and strategic direction across functions.

Responsible for the following:

Leading the development and implementation of the US strategy and plan for US MA activities for aHUS by providing medical leadership, insight and strategic guidance to the US aHUS medical team.

In partnership with the Executive Medical Director, providing medical strategic and tactical plans for late-phase pipeline program for Rare Nephrology as well as future LCM and potential late phase pipeline programs in the therapeutic area.

Leading the situational assessment of the patient journey and the US product strategy development including harmonization of activities involving KOLs cross-functionally.

Developing in-year medical strategy and tactical plan for the US Medical Affairs team for aHUS

Contributing scientific and medical acumen as well as the US perspective to registration programs working closely with GMA

Providing medical review and assurance of alignment with aHUS/Rare Nephrology strategic areas of interest for Investigator Sponsored Research (ISR) proposals.

Providing medical guidance, as appropriate, regarding scientific communication, internal medical training, external medical education (CME, Symposia, medical education), Medical Information.

Providing strategic medical leadership and appropriate medical input to cross-functional brand strategy

Support Head of US Rare Hematology & Nephrology with team’s performance in terms of goals and delivery of US medical plans.

Serving as a medical expert and resource within Alexion in support of the therapeutic area.

Leading content development and presentation for external medical education programs and other medical initiatives.

Developing, conducting, or contributing to therapeutic training programs for Alexion personnel.

Establishing strategic partnerships with Centers of Excellence and KOLs in areas of scientific interest and serving as a conduit for flow of information both out to the medical community and into the company.

Working closely with the Field Medical Team (Medical Science Liaisons and Field Directors) in the development and execution of US KOL medical engagement strategy as well as the development and implementation of the field medical strategic plan.

Establishing and/or enhancing partnerships with key academic institutions and developing relationships with key thought leaders.

Planning, designing and managing medical Advisory Boards and gathering insight from national/regional/local medical Advisory Boards or other insight-gathering activities.

Contribute to collaborations and engagements with professional societies and patient advocacy organizations in the therapeutic area

You will need to have:

Must have an MD, PhD or PharmD level degree or equivalent- Nephrology, Hematology, or Immunology experience would be a plus.

Significant experience in Medical Affairs and/or the biopharmaceutical industry, including development and execution of medical strategy.

Deep scientific and clinical expertise with the ability to translate complex data into strategic medical insights.

Demonstrated success leading cross-functional initiatives and influencing senior stakeholders in a matrix environment.

Strong understanding of the US healthcare, regulatory, and reimbursement landscape.

Proven ability to establish and maintain productive relationships with KOLs, academic institutions, professional societies, and external healthcare stakeholders.

The annual base pay for this position ranges from $206,827 to 310,240.80. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

07-Oct-2026

Closing Date

26-Nov-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Job details

Seniority
Director
Function
Medical Affairs
Therapeutic area
Not listed
Location
Boston, Massachusetts, United States of America
Employment type
Full time

How this role compares

Computed from every other active Medical Affairs role in our database, not just this employer's listings.

We currently track 301 comparable Director Medical Affairs roles across 55 biopharma companies.

301Comparable roles tracked
284Currently active
55Companies hiring similar roles
32Countries represented

Salary context

120 of 301 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject Not listed on this posting
Lowest disclosed · Principal Strategic Medical Writer · AbbVie $109,500/yr – $208,500/yr
Peer group range $159,000 – $392,100 (median $263,250)

Where these roles are based

Top locations among the 301 comparable roles

United States207
United Kingdom24
Canada9
China7
France6
Germany5

+ 26 more countries

Seniority mix

301 of 301 peers have a known seniority level

Director249
Senior Director37
Principal15

Therapeutic area mix

131 of 301 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Oncology63
Neuroscience18
Immunology14
Cardiovascular / CVRM8
Rare Disease7
Respiratory6
Dermatology & Aesthetics6
Gastroenterology6
Ophthalmology2
Vaccines & Infectious Disease1

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The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

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Notify me about similar jobs

Get an email when we spot other openings like this one – same job function, comparable seniority, roles you'd actually want to see.

Or follow a whole field: get every new Medical Affairs job in the United States, and choose locations and companies.

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

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Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.