(Associate Director) Senior Scientist Manufacturing global MS&T (Mainz, RP, DE, 55131)
About this opportunity
Mainz, Germany | full time | Job ID: 11298
About the Role
As Scientist Linker Payload Manufacturing, you will provide scientific and technical leadership for the manufacture of small molecule drug substances, linker-payloads, and related chemical entities in a highly regulated GMP environment. Your focus will be on manufacturing processes, process understanding, process robustness, scale-up, troubleshooting, and lifecycle management across late-stage clinical and commercial programs.
In this role, you will act as a key interface between internal technical functions and external manufacturing partners, ensuring that processes are transferred, executed, and continuously improved in a compliant, reliable, and scalable manner. You will help maintain technical oversight of manufacturing activities, support process-related investigations and changes, and contribute to robust supply for complex pharmaceutical products.
Your Contribution
Provide scientific and technical support for the manufacture, transfer, optimization, and lifecycle management of linker-payload manufacturing processes across external manufacturing networks
Act as a process-focused subject matter expert, maintaining deep technical understanding of manufacturing processes and serving as a key contact for process performance, process changes, and operational troubleshooting
Support process scale-up, technology transfer, process validation readiness, and implementation at manufacturing sites
Drive and support manufacturing investigations, root-cause analyses, deviations, change controls, CAPAs, risk assessments, and process improvement measures
Review, generate, and approve technical documentation such as manufacturing instructions, validation/qualification documents, investigation reports, process transfer packages, and regulatory support documentation
Collaborate closely with internal stakeholders such as Technical Development/CMC teams as well as external CDMOs/CMOs to ensure seamless communication and alignment
Contribute to harmonization of processes across sites while monitoring performance using KPIs/risk management tools to drive continuous improvement initiatives
Provide input to regulatory submissions and health authority responses related to manufacturing processes
A Good Match
Master’s degree or PhD in Organic Chemistry, Process Chemistry, Chemical Engineering or Pharmaceutical Sciences with 5+ years of relevant experience in a regulated pharmaceutical or biotech environment
Strong experience in GMP manufacturing of APIs/small molecule drug substances or chemical process development; experience with linker-payloads or ADC-related materials is a strong plus
Solid understanding of chemical manufacturing processes including transfer optimization scale-up lifecycle management & troubleshooting within GMP settings
Hands-on expertise in dealing with deviations change controls CAPAs investigations risk assessments & qualification/validation documentation under compliance frameworks
Familiarity with regulatory expectations for small molecule manufacturing including contributions towards IND/IMPD/BLA/MAA submissions or equivalent filings globally
Excellent stakeholder communication skills coupled alongside structured problem-solving abilities adaptable even amidst fast-paced operational demands
Fluent English communication skills, both written and spoken; Chinese language skills are a plus
Your Benefits:
It's our priority to support you:
Your flexibility: flexible hours | vacation account
Your growth: Digital Learning | Performance & talent development | leadership development | Apprenticeships | LinkedIn Learning
Your value: Your voice at the table | Culture on an equal footing | Opportunities to shape & impact | Support for your full potential
Your health and lifestyle: Company bike
Your mobility: Job ticket | Deutschlandticket
Your life phases: Employer-funded pension | Childcare
Apply now - We look forward to your application!
Apply to our Mainz, Germany location by sending us your documents via our online form. For any questions, contact our talent acquisition team on: + 49 (0) 6131-9084-1291 (Monday-Friday from 1 PM to 3 PM CET).
Job ID 11298 (please always specify if you have any questions)
By submitting your application, you acknowledge that a background check will be conducted as part of the recruitment process in accordance with applicable laws and regulations. If you are considered for the position, BioNTech will conduct the background check through our service provider ‘HireRight’. You will be informed accordingly by your BioNTech-Recruiter.
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Job details
How this role compares
Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.
We currently track 676 comparable Associate Director Manufacturing & CMC roles across 88 biopharma companies.
Salary context
185 of 676 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 676 comparable roles
+ 32 more countries
Seniority mix
676 of 676 peers have a known seniority level
Therapeutic area mix
2 of 676 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
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How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.