VP, Disease Business Unit General Manager, US

Job Description

Vertex is seeking a seasoned commercial executive to serve as VP U.S. General Manager (GM), accountable for end-to-end business performance, including results delivery, performance management, budget and strategic priorities for their designated portfolio, in the US. The VP GM will lead a fully integrated U.S. Business Unit, with responsibility for commercial execution through cross-functional alignment to sustain market leadership while preparing for future innovation.

Key Duties & Responsibilities 

Owns full P&L responsibility for the U.S. designated Business Unit, delivering against revenue, profitability, and long-range plan commitments

Leads an established commercial organization with opportunities for future builds with direct reports across Sales and Marketing

Drives cross-functional leadership and decision-making across Market Access, Patient Services, Analytics, Commercial Operations, Medical Affairs, R&D, Manufacturing, Legal, Regulatory, Government Affairs, and Patient Advocacy

Ensures continued excellence in launch execution for future indication expansions, and lifecycle management

Develops and maintains a high-performing leadership bench with strong succession planning

Serves as enterprise steward of Vertex’s designated therapeutic area franchise in the U.S., balancing near-term performance with long-term sustainability

Leads the organization through the dynamics of a highly penetrated, mature market

Partners with Medical Affairs and Patient Services to ensure patient-centric engagement models reflecting lifelong treatment journeys

Maintains trusted relationships with the Disease communities including advocacy organizations and treatment centers

Owns the U.S. revenue forecast, expense management, and resource allocation, in collaboration with the Business Unit Leadership.

Champions a culture of operational rigor, continuous improvement, and ethical leadership, ensuring full compliance with all company policies and regulatory standards

Required Experience

Typically requires 15+ years of pharmaceutical or biotech experience, with deep commercial leadership exposure

Minimum of 8–10 years of senior people leadership experience, including responsibility for large, matrixed organizations

Demonstrated success leading large, in‑market franchises with sustained performance over time

Preferred experience includes:

Portfolio and lifecycle management

Operating effectively within highly visible, enterprise‑critical franchises

Experience engaging externally with advocacy groups, policymakers, and senior healthcare stakeholders

Required Knowledge / Skills

Proven enterprise‑level commercial leadership with strong strategic, financial, and operational acumen

Ability to lead through scale and complexity, balancing performance delivery with long‑term franchise stewardship

Exceptional executive communication skills, with the ability to influence the EC, Board, and external stakeholder levels

Strong track record of building leaders, not just teams, and developing future general managers

Deep experience operating in cross‑functional, highly regulated environments

Demonstrated ability to manage significant budgets and complex trade‑offs

Uncompromising commitment to ethics, compliance, and Vertex’s values and reputation

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$368,000 - $552,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com