Sr. Director, Portfolio Strategy and Analytics | Onsite San Diego HQ

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit  neurocrine.com , and follow the company on  LinkedIn ,  X , Facebook and YouTube . ( *in collaboration with AbbVie )

About the Role:

Responsible for leading and advancing enterprise portfolio strategy, optimization, analytics, and resource planning capabilities across Neurocrine's research and development portfolio. Serves as a strategic advisor to executive leadership, providing data-driven insights and recommendations that support portfolio prioritization, investment decisions, resource allocation, and long-range planning. Leads highly complex portfolio planning and analytics activities with significant organizational impact, risk, and complexity. Develops and implements portfolio optimization frameworks, forecasting models, scenario analyses, and decision-support capabilities that enable effective governance and maximize portfolio value. Partners closely with R&D, Finance, Program Management, Business Development, and Executive Leadership to drive strategic decision-making across discovery, development, and lifecycle programs. Serves as the enterprise subject matter expert for portfolio planning systems, portfolio analytics, and resource optimization methodologies while driving continuous improvement of portfolio management capabilities across the organization. _

Your Contributions (include, but are not limited to):

Leads development and execution of enterprise portfolio strategy, prioritization, and optimization frameworks aligned with corporate and R&D objectives

Owns and manages Neurocrine's multi-year compound flow model, including risk-adjusted and non-risk-adjusted portfolio scenarios across therapeutic areas and development stages

Develops and maintains transition probability models across development stages and modalities to support portfolio forecasting, investment planning, and strategic decision-making

Leads executive-level portfolio prioritization and trade-off discussions, translating complex portfolio data into actionable recommendations that support portfolio investment and resource allocation decisions

Evaluates portfolio opportunities, risks, development scenarios, and investment alternatives to maximize overall portfolio value

Designs and oversees quantitative models supporting portfolio forecasting, probability of success analyses, development timelines, resource planning, and investment decision-making

Develops scenario analyses evaluating the impact of adding, removing, accelerating, delaying, or restructuring portfolio programs

Analyzes pipeline progression, development productivity, attrition rates, cycle times, and key portfolio performance indicators to support strategic planning and governance discussions

Leads enterprise resource planning and capacity forecasting activities across functions, therapeutic areas, and development stages.

Partners with Finance, Program Management, and functional leaders to align portfolio objectives with organizational capacity, budgetary constraints, and long-range planning assumptions

Develops portfolio-level financial models supporting annual operating plans, investment prioritization, resource planning, and budget forecasting activities

Identifies resource constraints, operational risks, and strategic opportunities and develops recommendations to optimize portfolio execution

Serves as business owner and subject matter expert for portfolio planning systems, including Planisware and related portfolio management platforms

Establishes portfolio data standards, governance processes, and analytics best practices to support high-quality portfolio decision-making

Drives implementation and continuous improvement of portfolio analytics tools, systems, reporting capabilities, and governance processes

Leads benchmarking initiatives evaluating development timelines, costs, resource models, productivity metrics, and industry best practices

Leverages AI-enabled tools, external data sources, and advanced analytics methodologies to enhance portfolio insights, forecasting accuracy, and competitive benchmarking capabilities

Develops executive dashboards, portfolio reviews, governance materials, and Board-level presentations

Provides analytical support for business development evaluations, external innovation opportunities, and strategic investment assessments

Leads cross-functional portfolio planning processes and governance forums to drive alignment, transparency, accountability, and execution excellence

Serves as a trusted advisor to executive leadership on portfolio strategy, prioritization, resource allocation, and long-term planning decisions

Provides leadership, coaching, and mentoring to team members and cross-functional partners

Other duties as assigned

Requirements:

BS/BA degree in Life Sciences, Business, Finance, Engineering, Data Analytics, Operations Research, or related discipline and 14+ years of relevant pharmaceutical, biotechnology, healthcare, consulting, portfolio management, strategy, or related industry experience OR

Master's degree in a related discipline and 12+ years of relevant experience OR

PhD, PharmD, MBA, or other advanced degree and 10+ years of relevant experience

Deep understanding of pharmaceutical drug development across discovery, preclinical, clinical, regulatory, and commercialization stages

Significant experience managing multi-year compound flow models and portfolio forecasting methodologies

Expert knowledge of portfolio strategy, portfolio management, resource planning, and investment decision-making frameworks

Extensive experience supporting portfolio governance processes and executive-level decision-making

Advanced experience with Planisware or comparable portfolio management and planning platforms

Experience implementing, managing, or optimizing portfolio planning systems, analytics capabilities, and governance processes

Strong understanding of portfolio valuation, probability of success modeling, scenario planning, forecasting techniques, and portfolio optimization methodologies

Experience leading enterprise portfolio planning and prioritization processes across complex, multi-asset development portfolios

Demonstrated success influencing senior leaders and facilitating executive-level portfolio prioritization, investment, and resource allocation decisions

Experience developing multi-year portfolio strategies and long-range planning scenarios aligned with organizational objectives

Experience supporting executive governance committees, portfolio review forums, and strategic planning processes

Strong understanding of R&D financial planning, budgeting, forecasting, and resource allocation processes

Experience leading portfolio benchmarking and competitive operational analyses

Experience preparing executive leadership and Board-level presentations and materials

Familiarity with AI-enabled analytics tools, advanced modeling techniques, and external benchmarking resources preferred

Ability to evaluate portfolio risks and opportunities and translate findings into strategic recommendations that influence organizational strategy and investment decisions

Strong strategic thinking, business acumen, and ability to integrate scientific, operational, financial, and portfolio considerations into decision-making

Exceptional communication, influence, stakeholder management, and relationship-building skills

Demonstrated ability to communicate complex analyses and strategic recommendations to diverse audiences, including senior executives

Strong analytical, critical thinking, problem-solving, and decision-making capabilities

Proven ability to lead through influence and achieve results within highly matrixed organizations

Demonstrated ability to develop innovative solutions to complex business challenges with significant organizational impact

Strong planning, prioritization, organizational, and project leadership skill

Ability to manage multiple competing priorities in a dynamic and evolving portfolio environment

Demonstrated ability to build partnerships and align stakeholders across functions and organizational levels

Strong attention to detail while maintaining an enterprise-wide perspective

Ability to mentor, coach, and develop others while fostering a culture of accountability and continuous improvement.

Advanced proficiency with portfolio management, business planning, analytics, forecasting, and reporting tools

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Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment , and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

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The annual base salary we reasonably expect to pay is $226,500.00-$309,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 35% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.