Senior Scientist, RNA Pilot Manufacturing

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”, a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

The RNA Process development team is seeking a Senior Scientist to lead an integrated RNA Pilot Manufacturing operation. This role will be responsible for delivering high-quality material with agility and speed across early and late-stage development.

This leader will be accountable for building and operating a phase-appropriate manufacturing model that enables rapid execution while maintaining quality, compliance, safety, and technical rigor. This role requires deep experience in a manufacturing environment, strong understanding of ALCOA principles, and the ability to lead cross-functional execution in a fast-paced, science-driven setting.

The Senior Scientist will partner closely with CMC functions including Analytical Development, Process Development, Quality and the GMP manufacturing facility to ensure seamless material delivery, technical readiness, operational excellence, and robust transfer of product and process knowledge across the manufacturing network.

Key Responsibilities

Lead and execute RNA manufacturing operations supporting nonGMP manufacturing activities.

Provide leadership for the RNA Pilot, ensuring scientific and technical understanding is seamless between process development through manufacturing execution.

Build and operate an agile development manufacturing model in the RNA space capable of rapidly delivering material for various program needs.

Ensure manufacturing operations are executed in a phase-appropriate manner, balancing speed, compliance, scientific rigor, and operational discipline.

Partner with analytical testing laboratories to ensure testing readiness, sample flow, analytical timelines, investigation support, and timely release of material.

Ensure operational readiness across people, process, materials, equipment, facilities, documentation, and testing prior to manufacturing execution.

Manage Pilot lab timelines and raw material inventory to ensure timely delivery of nonGMP RNA drug substance.

Drive technical problem-solving during manufacturing campaigns, including real-time escalation, root-cause analysis, and implementation of corrective and preventive actions.

Establish and manage systems for tracking process performance using ELN workflows and multivariate data analysis tools

Ensure learnings from manufacturing activities are captured, communicated, and incorporated into future strategies.

Qualifications & Experience

Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field BS with 8+ years’ experience in science related disciplines

MS with 6+ years’ experience in science related disciplines

PhD with 2+ years’ experience in science related disciplines

 

Experience in managing manufacturing timelines including raw material sourcing and inventory.

Experience in process unit operations relevant to RNA manufacturing including bioreactors, chromatography, and filtration.

Experience in scaling up in vitro transcription reactions.

Knowledge and understanding of technology transfer from PD to the pilot facility and from the pilot facility to GMP manufacturing.

Experience working with CROs to source phase appropriate DNA templates and other critical raw materials.

Strong track record of implementing standardized operations, KPI management, and production documentation systems.

Experience managing material flow, production scheduling, and cross-functional coordination.

Experience with compiling and interpreting RNA analytics and biophysical characterization techniques for RNA such as HPLC, CE, ELISAs, and cell based assays.

Prior management and mentorship experience; passion for people management and development

Ability to work independently as well as part of a team in a highly dynamic, fast-paced, matrixed environment with rapidly evolving priorities.

Excellent communication and interpersonal skills, with the ability to influence cross-functional stakeholders and present insights to all levels of senior stakeholders.

Demonstrated continuous improvement mindset, driving efficiencies, process improvements across diverse initiatives.

 

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

Cambridge - MA - US: $129,770 - $157,250


The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to  adastaffingsupport@bms.com . Visit  careers.bms.com/eeo-accessibility  to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only:  If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:  https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at  https://careers.bms.com/fraud-protection .

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at  TAEnablement@bms.com with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1607210 : Senior Scientist, RNA Pilot Manufacturing