Senior Scientist I/II - Oncology/Immuno-Oncology

Role Type: Onsite Working #LI-OnsiteLocation: Cambridge, Massachusetts, United StatesRelocation: Relocation assistance is available for this position Join Novartis Oncology-OIT (Oncology Immune Therapies) group for an exciting opportunity to make a significant impact on cancer immunology.As a key member of our dynamic, multidisciplinary team, you will contribute to the development of groundbreaking therapeutic modalities.Your work will play a crucial role in advancing new therapies and bringing our innovative drugs to patients.

Key Responsibilities:Support drug screening, novel target identification and validation, including working with replication-incompetent lentiviruses, mRNA-LNP, cell lines, primary cells, and tissuesDevelop and perform cell-based assays, flow cytometry, and biochemistry-based assays for drug discovery. Occasionally, you will also employ molecular biology (e.g. gel electrophoresis, cloning, qPCR, western blot, etc.) Conduct biological and pharmacological studies by developing and performing analyses of preclinical tissue samples provided by the in vivo teamEmploy good laboratory practices, data recording, analysis and documentationCollaborate effectively while working in a matrixed environmentPresent results in lab and department meetingsAssist in writing research documents and publicationsEssential Requirements:Bachelor’s degree in immunology, immuno-oncology, oncology, molecular or cell biology, or a related field is required. A master’s degree is preferred.5+ years of relevant laboratory experience in industryKnowledge of immunology and expertise in cancer biology and/or immunology are requiredExpertise in tumor immunology, especially T cell mediated anti-tumor activity is highly desiredProficiency in cell culture including cell lines and primary cells, and multi-color flow cytometry is required.Extensive hands-on experience with immune cell-based assays, including primary immune cell isolation, manipulation, phenotyping, and in vitro functional assays, as well as mammalian cell line culture is highly desired.Experience with molecular cloning, qPCR, reporter assays, ELISA, viral production and transduction, mRNA-LNP–mediated gene expression in primary cells, gene silencing (RNAi or CRISPR), or other target validation methods is a plus.Demonstrated ability to quickly learn and perform in new areas, implement new techniques and instrumentationStrong scientific motivation and rigor, with experience independently designing, developing, executing, and troubleshooting cell-based assays for drug discovery, are preferred.Excellent presentation, written and verbal communication, and interpersonal skills, with the ability to thrive in a fast-paced, collaborative environment.A record of accomplishments with peer-reviewed publications a plusWhat We OfferThis is a dual level posting and as such the salary for this position is expected to range between:Senior Scientist I: $93,800 - $174,200 per yearSenior Scientist II: $98,700 - $183,400 per yearThe final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here.