(Senior) Principal Scientist - siRNA expert DMPK (Biberach, Germany, Baden-Württemberg)
About this opportunity
The Position
Help shape the future of siRNA therapeutics by translating cutting-edge DMPK science into impactful drug discovery strategies. In your new role, you will provide scientific leadership, work within multidisciplinary project teams, and influence key decisions from lead optimization to clinical translation. Join us to advance innovative research and accelerate the translation of siRNA therapies from discovery to patients.
This position can be filled either as Principal Scientist or Senior Principal Scientist.
Discover our Biberach site: xplorebiberach.com
Tasks & responsibilities
As a recognized scientific expert in DMPK for siRNA therapeutics, you will provide scientific guidance and innovative solutions to pharmacokinetic and tissue disposition challenges across discovery research programs.
Furthermore, you will contribute to multiple multidisciplinary project teams by lead optimization, candidate selection, and translational strategies, thereby driving the success of siRNA-based drug discovery programs.
You will define and advance screening strategies with a focus on in vitro ADME, in vivo PK, and PK/PD to deepen the understanding of siRNA disposition, tissue targeting, efficacy, and safety, as well as coordinate DDS activities.
In research teams and stakeholder meetings, you will interpret, communicate, and influence DMPK strategies and key project decisions through scientific expertise.
The role will include the supervision of in vivo pharmacokinetic studies and the planning and coordination of relevant DMPK profiling activities.
Moreover, you will contribute to the development and application of innovative experimental and data analysis approaches to advance siRNA and oligonucleotide research.
Additional tasks for the Senior Principal Scientist role:
You will shape our siRNA strategy within the company while mentoring scientists and defining scientific best practices.
In addition, you will develop and implement new strategies in international projects and initiatives to continuously improve workflows and interfaces and represent the company’s delivery science externally in scientific networks, conferences and partnering discussions.
Requirements
PhD (or equivalent) in pharmacokinetics, drug metabolism, pharmacology, biology, pharmaceutical sciences, or related discipline
In-depth knowledge of DMPK, phys.-chem. profiling and formulation principles and proven track record in siRNA therapeutics
Several years of pharmaceutical industry experience in drug discovery of siRNA, with demonstrated success in translating preclinical findings into clinical development
Proven experience in the design, interpretation and ideally also supervision of in vivo PK studies of siRNA therapeutics
Excellent overview of scientific literature in the siRNA field as well as an already established scientific network
Strong communication and interpersonal skills, with the ability to collaborate effectively in international cross-functional teams and convey complex scientific concepts to diverse stakeholders
Additional requirements for the Senior Principal Scientist role:
Longterm professional experience within the pharmaceutical industry, including leadership of complex, cross-functional drug discovery projects and platform initiatives, and communication to senior leadership forum
Recognized scientific standing in the siRNA community, demonstrated by publications, patents, invited talks or successful external collaborations
Start date: asap
As part of our commitment to transparency and fairness, salary information will be shared during the recruitment process. We also offer a comprehensive benefits and wellbeing package.
Applications from persons with severe disabilities are warmly welcomed. In cases of equal qualifications, such applicants will be given preferential consideration in the selection process.
Ready to contact us?
If you have any questions about the job posting or process - please contact our HR Direct Team, Tel: +49 (0) 6132 77-3330 or via mail: hr.de@boehringer-ingelheim.com
Recruitment process:
Step 1: Online application - The job posting is presumably online until October 15th, 2026. We reserve the right to take the posting offline beforehand.
Step 2: Virtual meeting in the period from mid till end of October
Step 3: On-site interviews beginning of November
Please submit your application documents in English.
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Job details
How this role compares
Computed from every other active Drug Discovery & Preclinical Research role in our database, not just this employer's listings.
We currently track 227 comparable Principal Drug Discovery & Preclinical Research roles across 44 biopharma companies.
Salary context
92 of 227 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 227 comparable roles
+ 7 more countries
Seniority mix
227 of 227 peers have a known seniority level
Therapeutic area mix
30 of 227 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
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Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
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