Senior Medical Director US Respiratory Inhaled

Location: Wilmington, Delaware

Hybrid: 3 days a week onsite

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

Role Summary 

The Senior Medical Director provides strategic and hands-on medical leadership across AstraZeneca's US inhaled respiratory portfolio. The role leads healthcare strategy, data creation, scientific dissemination, and external engagement. As a member of the Core Medical Team, this individual serves as the Voice of Medical, influences across US, Global, and R&D partners, and directly owns selected tactical results.

Leadership Profile 

Strategic and enterprise-minded; scientifically rigorous; collaborative and influential; comfortable with ambiguity; accountable for results; able to prioritize and execute; committed to integrity, inclusion, and patient-focused decision-making.

Key Responsibilities 

Lead development and execution of US medical strategy and annual medical plans across the inhaled respiratory portfolio.

Serve as the Voice of Medical in Core Medical Teams and cross-functional forums, providing clear scientific leadership and influencing portfolio, brand, launch, and investment decisions.

Establish US evidence priorities and coordinate integrated plans spanning clinical analyses, observational data studies, applied research, health outcomes research, externally sponsored research, and publications.

Lead scientific narrative development and ensure evidence is translated into accurate, balanced, and clinically meaningful communications for internal and external audiences.

Provide strategic oversight of publication and congress plans, scientific platforms, advisory boards, medical education, and Field Medical priorities.

Build trusted relationships with external experts, professional societies, health systems, and strategic partners; use insights to shape medical strategy and improve translation of evidence into practice.

Partner with Field Medical Affairs to set, drive and measure key performance indicators, summarize insights and ensure tactics and materials are aligned to strategy.

Lead or supervise implementation science, quality-improvement, and healthcare-system initiatives that address barriers to guideline-directed respiratory care.

Partner closely with Commercial, Market Access, HEOR, Regulatory, Clinical Development, Global Medical, Patient Safety, Medical Information, and Medical Excellence.

Serve as a medical reviewer and approver for promotional and non-promotional materials; directly support MLR review, scientific claims, training, congress, and field materials as business needs require.

Mentor Medical Directors and matrix team members; build alignment, accountability, and high-quality execution across complex initiatives.

Ensure all activities meet AstraZeneca policies, regulatory requirements, ethical standards, and expectations for scientific integrity.

Essential Qualifications 

MD, DO, PharmD, PhD,

At least 5 years of combined relevant clinical, scientific, healthcare, and pharmaceutical industry experience, including Medical Affairs experience.

Demonstrated success leading US medical strategy, evidence generation, scientific communications, and external scientific engagement in a complex matrix organization.

Demonstrated excellent scientific judgment, business acumen, communication, stakeholder management, and influencing skills.

Ability to move effectively between strategic leadership and hands-on execution.

Proven track record to collaborate and build internal/external networks, lead field medical strategies and training, and translate complex science into compelling, accessible, and compliant messages for diverse audiences

Strong understanding of the US healthcare, regulatory, compliance, payer, and provider environment, including experience with MLR or comparable medical review processes.

Preferred Qualifications 

Expertise in respiratory medicine, asthma, COPD, pulmonary pharmacology, or a related therapeutic area.

Experience with real-world evidence, implementation science, healthcare-system partnerships, publication strategy, congress planning, or Field Medical leadership.

Experience leading across multiple brands, markets, indications or lifecycle stages.

The annual base pay for this position ranges from $243,586.40 - $365,379.60 USD Annual and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Apply Now!

Date Posted

30-Sept-2026

Closing Date

15-Oct-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.