Scientist II, Oligonucleotides

<p>Who We Are <br /><br />BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions.<br /><br />Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions.<br /><br />Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world. <br /><br />About Worldwide Research and Development <br /><br />From research and discovery to post-market clinical development, our R&amp;D engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. <br /><br /></p><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;"><b>Scientist II, Bioconjugation Chemist Job Summary:</b></div><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;">BioMarin is seeking a dedicated and skilled Scientist II specializing in bioconjugation chemistry to contribute to our cutting-edge research and development efforts in nucleic acid-based therapeutics. The successful candidate will be responsible for designing and synthesizing bioconjugates, including antibody-drug conjugates (ADCs), antibody-oligo conjugates (AOCs), and other complex biomolecules. This role requires a strong background in organic chemistry, bioconjugation techniques, and analytical characterization methods. This role offers a unique opportunity to be part of a dynamic team at the forefront of biotechnology innovation, working on projects that have the potential to transform patient outcomes.</div><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;"><b>Key Responsibilities:</b></div><ul style="text-align: left;margin: 0.0pt;padding-left: 0.0pt;list-style-position: inside;list-style-type: disc;"><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 14.4px;margin: 0.0pt 0.0pt 8.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Engage actively in project team discussions across the organization, providing subject matter expertise to support the progression of research projects and the development of new methodologies.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 14.4px;margin: 0.0pt 0.0pt 8.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Design and synthesize bioconjugates such as antibody-oligo conjugates (AOCs), peptide conjugates, and other complex biomolecules.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Develop and optimize conjugation methodologies and purification processes.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Characterize bioconjugates using various analytical techniques, including HPLC, LC-MS, SDS-PAGE, and spectroscopy.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Collaborate with cross-functional teams, including Biology, Pharmacology, and Process Development, to support preclinical and clinical programs.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Maintain accurate and detailed laboratory records and documentation.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Present research findings to internal teams and at scientific meetings.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Stay up-to-date with the latest advancements in bioconjugation chemistry and related fields.</li></ul><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;"><b>Qualifications:</b></div><ul style="text-align: left;margin: 0.0pt;padding-left: 0.0pt;list-style-position: inside;list-style-type: disc;"><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Ph.D. in Chemistry, Biochemistry, or a related field with a focus on bioconjugation techniques and organic synthesis.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Minimum of 3-5 years of postdoctoral experience or industry experience in bioconjugation chemistry.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Proven track record in designing and synthesizing bioconjugates, including AOCs and peptide conjugates.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Strong knowledge of analytical techniques for characterizing bioconjugates.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Excellent problem-solving skills and the ability to work independently and collaboratively.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Strong written and verbal communication skills.</li></ul><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;"><b>Why Join BioMarin?</b></div><ul style="text-align: left;margin: 0.0pt;padding-left: 0.0pt;list-style-position: inside;list-style-type: disc;"><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Opportunity to work on cutting-edge biopharmaceuticals that make a meaningful impact on patients' lives.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Collaborative and innovative work environment.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Comprehensive benefits package, including health insurance, 401(k) matching, and professional development opportunities.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Located in the beautiful San Francisco Bay Area with access to a vibrant scientific community.</li></ul><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;"><b>Skills:</b></div><ul style="text-align: left;margin: 0.0pt;padding-left: 0.0pt;list-style-position: inside;list-style-type: disc;"><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Demonstrated ability to work independently as well as part of a collaborative team environment, with a proactive approach to problem-solving and advancing research programs.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Commitment to maintaining up-to-date knowledge of advancements in oligonucleotide chemistry and related fields, with a willingness to engage in ongoing professional development.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Expertise in solid-phase oligonucleotide synthesis and purification, with a strong track record of successful project outcomes.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">Excellent written and verbal communication skills, with the ability to effectively present data and findings to both technical and non-technical audiences.</li></ul><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: 15.0pt;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 3.75pt 3.75pt 3.75pt 0.0pt;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);text-align: left;text-indent: 0.0px;"><b>Work Style:</b></div><ul style="text-align: left;margin: 0.0pt;padding-left: 0.0pt;list-style-position: inside;list-style-type: disc;"><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">This is an onsite daily role in San Rafael, CA.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">This role will have a daily presence in our Research labs executing experiments.</li><li style="font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size: 11.0pt;color: rgb(0,0,0);text-indent: 0.0pt;line-height: 15.0pt;margin: 5.0pt 0.0pt 5.0pt 26.5pt;list-style-position: inherit;list-style-type: inherit;">This position represents an exciting opportunity to contribute to BioMarin's mission of developing innovative therapies for patients with serious and life-threatening conditions. We look forward to welcoming a passionate and skilled oligonucleotide chemist to our team.</li></ul><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: inherit;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 0.0px;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);"></div><div style="border: 0.0px;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;font-size: 11.0pt;line-height: inherit;font-family: Aptos , Aptos_EmbeddedFont , Aptos_MSFontService , Calibri , Helvetica , sans-serif;font-size-adjust: inherit;margin: 0.0px;padding: 0.0px;vertical-align: baseline;color: rgb(0,0,0);"></div><p><br /><br />Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. <br /><br />Equal Opportunity Employer/Veterans/Disabled <br /><br />An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.<br /><br />Ireland Safety Responsibility<br />Support the organization’s commitment to environmental protection, injury prevention, and continual improvement of EHS management systems. Actively contribute to a safe and environmentally responsible workplace by identifying hazards, reporting incidents and participating in EHS initiatives and training.</p>