About this opportunity

<div><div>BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions. Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions. Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world. About Technical Operations BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. SUMMARY The Analytical Sciences team within Technical Development Services at BioMarin Pharmaceutical Inc. is seeking Scientist 2 to support protein/enzyme replacement therapy, small molecule, peptide and oligo programs. Reporting to the Associate Director of Analytical Sciences, this person will be a member of Glycan Analysis and Biophysical Characterization team. The successful candidate will lead the development, qualification, transfer, and lifecycle management of analytical methods, with a strong emphasis on glycan characterization and product quality attribute assessment. The role requires hands-on expertise in LC-MS, HILIC, CE, cIEF/icIEF, SEC, IEX, RP chromatography, and other orthogonal analytical techniques to support product characterization, control strategy development, comparability assessments, process and formulation development, and regulatory submissions. The ideal candidate is a self-motivated, agile scientist with deep expertise in glycan analysis, a broad analytical background across multiple modalities, and the ability to rapidly learn new technologies. Strong communication, collaboration, and problem-solving skills are essential, as this individual will partner closely with cross-functional teams across Analytical Sciences, Process Development, Formulation Development, Quality, Regulatory Affairs, and Research in a fast-paced environment. Experience supporting CMC development, regulatory submissions, and compliance with USP, ICH, and global regulatory expectations is highly desirable. We are seeking a scientifically curious and collaborative analytical scientist who combines deep glycan characterization expertise with the versatility to address diverse analytical challenges across multiple therapeutic modalities. RESPONSIBILITIES <ul style="margin: 0.0pt;padding-left: 0.0pt;"><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Lead analytical method development, qualification, transfer, remediation in support of process development and product characterization activities for clinical and commercial portfolio consisting of various modalities across different phases of CMC development.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Support pre- and post-IND regulatory submission by authoring and reviewing analytical sections and responding to queries from regulatory agencies.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Develop and optimize chromatography-, capillary-, spectroscopy-, and mass spectrometry-based analytical methods with a focus on Glycan Analysis.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Prepare, review, and approve analytical and technical protocols and reports.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Document experiments, data, and findings electronically in an accessible manner for inspections.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Participate in the general lab and instrument maintenance. </li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Mentor junior scientist(s) and research associate(s) in the team as needed.</li></ul> EXPERIENCE Required Skills:<ul style="margin: 0.0pt;padding-left: 0.0pt;"><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Strong expertise in glycan characterization and analysis, including method development, qualification, troubleshooting, and data interpretation using LC-MS, CE-based methods, cIEF, HILIC-FLD/MS, and other orthogonal analytical techniques relevant to biologics and complex modalities.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Hands-on experience with separation science and mass spectrometry, including LC-MS and chromatographic techniques such as SEC, IEX, RP, and HILIC, along with common detection platforms (UV, CAD, ELSD, FLD, and MS). Ability to integrate data from multiple analytical platforms to solve complex characterization challenges.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Experience developing and executing phase-appropriate analytical methods to support drug substance (DS), drug product (DP), formulation development, process characterization, comparability, and control strategy activities across clinical and commercial stages.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Broad analytical development experience with biologics and an interest in applying scientific knowledge across multiple molecular modalities and platforms.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Working knowledge of USP, ICH, and global regulatory expectations from health authorities including FDA, EMA, PMDA, and other international agencies.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Excellent scientific communication skills with demonstrated ability to effectively present data, write technical reports, influence cross-functional teams, and communicate complex scientific concepts to diverse audiences. </li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Strong problem-solving and critical-thinking skills with the ability to independently drive investigations and make technically sound, data-driven decisions.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Demonstrated ability to thrive in a fast-paced, dynamic environment, manage multiple priorities simultaneously, and rapidly learn and apply new analytical technologies and scientific concepts.</li></ul> Desired Skills:<ul style="margin: 0.0pt;padding-left: 0.0pt;"><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Experience with advanced characterization techniques such as CE-SDS, icIEF/cIEF, intact mass analysis, peptide mapping, glycan profiling, and other mass spectrometry-based workflows.</li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Familiarity with small molecules and conjugated molecules, analytical techniques and characterization approaches is a plus. </li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Experience authoring, reviewing, or supporting regulatory submissions, including INDs, BLAs, MAAs, and responses to health authority questions. </li><li style="font-family: serif;font-size: 10.0pt;margin: 0.0pt 0.0pt 0.0pt 26.5pt;padding-left: 9.5pt;text-indent: 0.0pt;">Demonstrated ability to quickly learn new technologies, expand technical expertise beyond a primary specialty area, and contribute across a broad range of analytical activities.</li></ul> EDUCATIONScientist 2:PhD degree in Chemistry, Biochemistry, pharmaceutical chemistry or related field with 4+ years of relevant post-graduate experience. (OR) Master’s degree in chemistry, Biochemistry, pharmaceutical chemistry or related field with 8+ years of relevant post-graduate experience. Sr. Scientist 1:PhD degree in Chemistry, Biochemistry, pharmaceutical chemistry or related field with 6+ years of relevant post-graduate experience. (OR) Master’s degree in chemistry, Biochemistry, pharmaceutical chemistry or related field with 10+ years of relevant post-graduate experience. CONTACTSWill report to Associate Director of Analytical Sciences and interface with internal department leaders and external partners from Research and Early Development, Technical Development, Quality, and Regulatory ONSITE, REMOTE, OR FLEXIBLE Full-time onsite Mon-Friday in Novato, CA TRAVEL REQUIRED None to minimal (0-5%). Occasional travel is only based on business needs. Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.</div></div>

Job details

Seniority

Not listed

Function

Drug Discovery & Preclinical Research

Therapeutic area

Not listed

Location

Novato, United States

Employment type

Fulltime-Regular

How this role compares

Computed from every other active Drug Discovery & Preclinical Research role in our database, not just this employer's listings.

We currently track 458 comparable Drug Discovery & Preclinical Research roles across 60 biopharma companies.

458Comparable roles tracked

443Currently active

60Companies hiring similar roles

19Countries represented

Salary context

176 of 458 peers report a salary range (USD, annualized)

Peers share this role's job function. This posting doesn't list a seniority level, so peers aren't narrowed by seniority either -- the range below may span more levels than usual.

This roleSubject Not listed on this posting

Lowest disclosed · Executive Director, Oncology Translational Medicine, Clinical Pharmacology Modeling and Simulation · GlaxoSmithKline LLC $0/hr – $0/hr (≈ $0–$0/yr)

Highest disclosed · AVP/ Head, Quantitative Pharmacology & Pharmacometrics - Oncology · Merck $282,200/yr – $444,200/yr

Peer group range $0 – $363,200 (median $180,250)

Where these roles are based

Top locations among the 458 comparable roles

United States347

United Kingdom16

India15

Canada12

Germany10

Switzerland10

+ 13 more countries

Seniority mix

365 of 458 peers have a known seniority level

Senior104

Principal80

Intern/Fellow/Postdoc64

Director39

Associate24

Associate Director23

Senior Director15

Manager8

Executive/VP8

Therapeutic area mix

60 of 458 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Oncology25

Immunology11

Neuroscience7

Cardiovascular / CVRM6

Vaccines & Infectious Disease3

Respiratory3

Rare Disease3

Gastroenterology1

Ophthalmology1

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How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

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Function Therapeutic area Seniority Country

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Function Therapeutic area Seniority Country

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Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.

Scientist 2, Separations and Biophysics Assays

About this opportunity

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