Principal Scientist I - In vivo Preclinical Development
About this opportunity
Company Description
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.
Job Description
The Principal Scientist, In Vivo Preclinical Development will play a key role in the pre-clinical team generating IND-enabling data for selection of targeted lipid nanoparticle (tLNP) drug development candidates for various indications, including autoimmune disorders. The individual will serve as a lead scientist developing, executing and communicating novel bioanalytical development strategies that achieve project specific and therapeutic modality development goals.
Designs, optimizes, executes, and troubleshoots in vivo animal studies and bioanalytical endpoints supporting these in vivo studies.
Develops protein detection assays via multiple means including flow cytometry, ELISA, and derivative technologies.
Develops robust assays for characterization of immune parameters such as phenotyping and receptor expression, cytokine expression profiling in blood and tissues from preclinical animal studies or in vitro experiments.
Coordinates with contract research organizations (CROs) and/or collaborative research teams for the purpose of executing bioanalytical assays required for in vivo screening activities.
Maintains good laboratory practice-like activities including ALCOA+ online laboratory notebooks, instrument and reagent qualification, and documentation.
Primary author and reviewer of publications, presentations and study reports/regulatory documents.
Works cross-functionally with other Research, CMC, Clinical and/or Regulatory functions to align the product strategy with program, portfolio, and corporate goals.
Present data (written and oral) and participate in project team meetings and cross-departmental team meetings.
Qualifications
BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience; PhD with typically 6+ years of experience in area or scientific area of discipline.
Demonstrated proficiency with complex multi-color flow cytometry panel development and experience in phenotypic analysis of multiple immune cell populations and markers of activation/exhaustion.
Experience in data analysis software including FlowJo, CellEngine, GraphPad Prism and Tableau.
Experience in molecular biology techniques such as ddPCR or Luminex/MSD-based assays.
Demonstrated ability to function as a principle investigator, generating original technical ideas and research or development strategies.
Demonstrate creative 'out of the box' thinking to solve difficult technical problems and champion new technologies to achieve project goals.
Recognized and sought out as an expert in his/her discipline within the company and possibly externally.
Experienced and demonstrated success as primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
Demonstrated scientific communication and presentation skills by presenting at leading scientific conferences.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Job details
How this role compares
Computed from every other active Clinical Development role in our database, not just this employer's listings.
We currently track 440 comparable Principal Clinical Development roles across 66 biopharma companies.
Salary context
183 of 440 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 440 comparable roles
+ 29 more countries
Seniority mix
440 of 440 peers have a known seniority level
Therapeutic area mix
96 of 440 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
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How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.