Vertex Pharmaceuticals Inc (US) Posted September 8, 2026

Principal Analyst, Project Portfolio Management Technology

Boston, United States Full time
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Vertex Pharmaceuticals Inc (US) is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

Job Description

General Summary:

The Business Engagement & Technology Principal Analyst will be a technical resource in ensuring delivery and support of commercial-off-the-shelf (COTS) and a wide range of custom solutions in support of their business partners. The Business Engagement & Technology Principal Analyst will partner with business leadership to deliver capabilities and execute on a roadmap that align to support business strategy . Additionally, the Business Engagement & Technology Principal Analyst will maintain reliable, scalable and compliant systems that easily meet business needs by efficient delivery and enhancements that provides opportunities for developing and implementing innovative solutions and integrations.

Key Duties and Responsibilities:

Become a trusted partner of the business leaders within their remit

Understand their needs and vision, and deliver technology solutions to support and enable their goals and objectives

Provide insights on how technology can improve business processes to enable operating efficiencies and support the achievement of business goals and objectives.

Help refine and execute the technology strategy by leading the evaluation, selection, implementation, and ongoing maintenance of technology solutions.

Develop and maintain a long term life cycle plan for the ongoing maintenance and management of systems.

Manage relationships with our strategic software vendors and service providers

Work closely with DTE Compliance, Internal Audit, and Quality Assurance groups as needed to ensure compliance with all appropriate regulations, as well as our DTE system lifecycle and change management requirements

Knowledge and Skills:

In-depth knowledge in the core disciplines of project management, business analysis, solution design, delivery, and testing

Experienced in building productive partnerships with business stakeholders and aligning them around a recommendation/solution

Strong understanding of the business, processes, and any appropriate regulatory environments

Results oriented contributor with a proven track record of on-time project delivery for large, complex projects with global stakeholders

Able to manage own workload with minimal direction

Very strong written and verbal communication skills and strong ability to present complex or sensitive information in a clear and concise manner to various technical and non-technical audiences

Exceptional analytical, quantitative, problem-solving, and prioritization skills

Strong system life cycle expertise

Good knowledge of running IT managed services or outsourced/ offshore teams

Very strong MS Office skills, including MS Project Server & Visio, Excel and PowerPoint experience

Experience in Agile methodology

Education and Experience:

Bachelor's degree in technology discipline or equivalent

6 years relevant business systems in the Life Sciences industry, or the equivalent combination of education and experience

#LI-HYBRID #LI-JS1

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$142,800 - $214,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

1.    Hybrid: work remotely up to two days per week; or select

2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Job details

Seniority
Principal
Function
BD&L & Strategic Planning
Therapeutic area
Not listed
Location
Boston, United States
Employment type
Full time

How this role compares

Computed from every other active BD&L & Strategic Planning role in our database, not just this employer's listings.

We currently track 115 comparable Principal BD&L & Strategic Planning roles across 42 biopharma companies.

115Comparable roles tracked
109Currently active
42Companies hiring similar roles
18Countries represented

Salary context

39 of 115 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject $142,800/yr – $214,200/yr
Lowest disclosed · Senior IAM Engineer M&A (Hybrid) · AbbVie $96,500/yr – $183,500/yr
Highest disclosed · Global Tech Sr Strategist · IQVIA $163,100/yr – $453,700/yr
Peer group range $140,000 – $308,400 (median $232,750)

Where these roles are based

Top locations among the 115 comparable roles

United States69
China15
United Kingdom5
Japan5
South Korea3
Switzerland3

+ 12 more countries

Seniority mix

115 of 115 peers have a known seniority level

Director94
Senior14
Principal7

Therapeutic area mix

27 of 115 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Neuroscience10
Oncology9
Immunology5
Respiratory2
Vaccines & Infectious Disease1

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

60%similar
Novartis Cambridge (USA), United States Principal
Same function Same seniority Same country
50%similar
Pfizer New York City, United States Director
Same function Adjacent seniority Same country
50%similar
Amgen Inc. Remote, United States Director
Same function Adjacent seniority Same country
50%similar
Boehringer Ingelheim Fremont, California, United States Director
Same function Adjacent seniority Same country
50%similar
Boehringer Ingelheim Ridgefield, Connecticut, United States Director
Same function Adjacent seniority Same country
50%similar
Merck Rahway, New Jersey, United States Director
Same function Adjacent seniority Same country

Notify me about similar jobs

Get an email when we spot other openings like this one – same job function, comparable seniority, roles you'd actually want to see.

Or follow a whole field: get every new BD&L & Strategic Planning job in the United States, and choose locations and companies.

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

60%
Principal Scientist II, Translational Biomarker Strategy Lead
Novartis · Cambridge (USA), United States · Principal
Function Therapeutic area Seniority Country
50%
Director, Business Development/KAM, Fremont CA/Bay Area (Fremont, CA, United States, California)
Boehringer Ingelheim · Fremont, California, United States · Director
Function Therapeutic area Adjacent seniority Country
50%
Director, Pipeline Commercialization Strategy (PCS) - Prostate
AbbVie · North Chicago, IL · Director
Function Therapeutic area Adjacent seniority Country
50%
Director, Employee Experience and Talent Strategy
AstraZeneca · Wilmington, Delaware, United States of America · Director
Function Therapeutic area Adjacent seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.