MES Engineer/Specialist
Notify me about similar jobsAbout this opportunity
Overview
Sanofi Manufacturing & Supply is preparing its future through an ambitious program named Modulus. The Modulus Project is at the cornerstone of Sanofi's strategy, aiming to create a new generation of evolutive multi-product facilities that are modular, adaptable, and agile, while leveraging disruptive technologies to better address vaccine and biologics manufacturing challenges.
The MES Specialist / MES Engineer is responsible for supporting the operation, monitoring, maintenance, and continuous improvement of the OpCenter Pharma Manufacturing Execution System (MES) within the Modulus Singapore facility. The role ensures the MES operates reliably and in compliance with GxP, data integrity, and validation requirements, supporting uninterrupted production execution and electronic batch record (EBR) workflows.
Key Responsibilities
MES Operations & Support
Support the day-to-day operation, monitoring, and maintenance of the OpCenter Pharma MES to ensure system availability, reliability, and performance.
Ensure the MES functions correctly for production execution and EBR workflows.
Participate in night call / after-hours support rotations, performing first-level troubleshooting and escalating complex issues as needed.
Own the MES platform end-to-end, including operations, administration, and configuration, with minimal supervision.
Prioritize MES incidents and keep the MES Manager and stakeholders informed of downtime and major incidents.
PI Modeling & Master Data Management
Execute PI changes and master data updates in OpCenter Pharma, following established standards and change control procedures.
Maintain a well-structured master data environment by applying and enforcing naming conventions, hierarchies, and data governance rules.
Apply good PI modeling practices (modular, reusable, scalable), flagging and remediating suboptimal or legacy designs.
Investigations, Deviations & Compliance
Support investigations into MES incidents and deviations, including data gathering, documentation, and root cause analysis.
Lead MES investigations where required, defining and implementing CAPA in line with GMP requirements.
Ensure compliance with GxP, data integrity, and validation requirements in all MES configuration and change activities.
Cross-Functional Collaboration & Documentation
Collaborate with Manufacturing (MFG), Quality Assurance (QA), Smart Factory, and Digital teams to translate business requirements into robust MES solutions.
Advise MFG and QA on MES data, design, and system usage.
Contribute to and maintain technical documentation, including SOPs, work instructions, and design specifications, to support audit readiness.
Core Competencies
Working knowledge of OpCenter Pharma or similar MES platforms, including configuration and administration.
Understanding of PI modeling concepts and manufacturing execution in a pharmaceutical setting.
Familiarity with GxP, data integrity, CSV/CSA, and change control principles.
Strong analytical and troubleshooting skills with a structured problem-solving approach.
Effective communication, teamwork, and sound escalation judgment.
SQL or scripting skills are a plus; knowledge of MES integration with SCADA, ERP, PLCs, or Smart Factory/IIoT platforms is an advantage.
Technical & Educational Background
Bachelor's degree in Engineering, Pharmaceutical, Life Sciences, or a related field (or equivalent experience).
1–10 years of experience supporting or administering an MES in a GMP-regulated pharmaceutical, biotech, or similar manufacturing environment.
Hands-on OpCenter Pharma experience.
Experience with master data and PI/process definitions within an MES or similar manufacturing IT system.
Experience in on-call / after-hours production support is a plus.
Job Expectations
Based in Tuas South, Singapore.
Participation in night call / after-hours support rotations for MES issues.
May require operational standby support for critical system breakdowns.
Pursue progress , discover extraordinary
Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.
At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.
Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com !
Job details
How this role compares
Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.
We currently track 3428 comparable Manufacturing & CMC roles across 175 biopharma companies.
Salary context
813 of 3428 peers report a salary range (USD, annualized)
Peers share this role's job function. This posting doesn't list a seniority level, so peers aren't narrowed by seniority either -- the range below may span more levels than usual.
Where these roles are based
Top locations among the 3428 comparable roles
+ 55 more countries
Seniority mix
1516 of 3428 peers have a known seniority level
Therapeutic area mix
22 of 3428 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
Notify me about similar jobs
Get an email when we spot other openings like this one – same job function, comparable seniority, roles you'd actually want to see.
Or follow a whole field: get every new Manufacturing & CMC job in Singapore, and choose locations and companies.
How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.