AstraZeneca Posted September 29, 2026

Director, Cancer Vaccine Preclinical Strategy

Boston, Massachusetts, United States of America Full time
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AstraZeneca is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

The Director of Cancer Vaccine Preclinical Strategy is responsible for leading efforts to develop and deliver a portfolio of  the new modalities to train the immune system to recognize and eliminate malignant cells. The Director will build on previous experience in cancer vaccines to exploit various vaccine platforms to drive long-lived, robust immune responses to prevent, treat, and drive long-lived surveillance of tumors. Building on the current state of the field, the Director will be tasked with developing preclinical strategy, guiding antigen discovery, supporting vaccine design, and developing combinatorial approaches to amplify clinical impact. The candidate will lead work across cross-functional teams to build programs. The Director will be responsible for driving collaboration and influencing internal stakeholders. In addition, the Director will develop and build a cutting-edge portfolio of intellectual property, guiding a team that fosters high-performance and innovation; building capabilities across immunology, oncology, and translational sciences; and establishing clear operating mechanisms to accelerate decision-making and delivery.

Accountabilities

·       Develop a preclinical pipeline for the design, testing, and delivery of cancer vaccine programs

·       Implement a strategy to explore multiple vaccine modalities to train immunity to eliminate tumors

·       Create an approach to evaluate combinatorial modalities to maximize control, clearance, and surveillance

·       Develop a strategy to drive target discovery and evaluation

·       Work with cross-disciplinary teams to guide iterative antigen design and preclinical evaluation

·       Establish strategic relationships across the organization and functions

·       Build animal models for rapid evaluation of emerging modalities

·       Support the development of a regulatory strategy  to translate programs to clinic

·       Create and foster effective relationships with senior and executive stakeholders in Research, Bioprocess Development, Clinical and Translational Medicine and Global Project Teams to ensure alignment across functions

·       Pioneer AI based strategies to accelerate the pace of innovation at all levels of research

·       Collaborate and guide the evaluation of novel business development opportunities

·       Communicate results internally and externally, as well as their associated risks, uncertainties and limitations

·       Define the training standards for junior colleagues in line with best practices and principles

Qualifications

·       PhD or equivalent in immunology, oncology, molecular biology, biochemistry or a related discipline with 10+ yrs industry experience

·       Proven experience developing novel immunological approaches to deploy immunity to fight tumors

·       Proven experience with immune profiling, tumor modelling, systems biology, and/or immune oncology

·       Experience working in a cross-functional team to maximize expertise and accelerate success

·       Experience developing and implementing novel methods to support vaccine development

·       Experience supporting or leading interdisciplinary vaccine discovery or development programs

·       Proven experience leading and managing junior colleagues

·       Proven experience developing and controlling budgets

·  Excellent written and verbal communication, business analysis, and consultancy skills

The annual base pay for this position ranges from $175,498.40 - $263,247.60 USD. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

29-Sept-2026

Closing Date

12-Oct-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Job details

Seniority
Director
Function
Drug Discovery & Preclinical Research
Therapeutic area
Oncology
Location
Boston, Massachusetts, United States of America
Employment type
Full time

How this role compares

Computed from every other active Drug Discovery & Preclinical Research role in our database, not just this employer's listings.

We currently track 127 comparable Director Drug Discovery & Preclinical Research roles across 35 biopharma companies.

127Comparable roles tracked
124Currently active
35Companies hiring similar roles
11Countries represented

Salary context

65 of 127 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject Not listed on this posting
Lowest disclosed · Principal Scientist--Pharmacokinetics, Dynamics and Metabolism · Pfizer $106,000/yr – $176,600/yr
Highest disclosed · Senior Director, Toxicology · Regeneron Pharmaceuticals, Inc (USA) $242,000/yr – $403,300/yr
Peer group range $141,300 – $322,650 (median $217,300)

Where these roles are based

Top locations among the 127 comparable roles

United States106
United Kingdom4
China4
India3
Germany2
China's Mainland2

+ 5 more countries

Seniority mix

127 of 127 peers have a known seniority level

Principal75
Director38
Senior Director14

Therapeutic area mix

22 of 127 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Oncology9
Immunology6
Cardiovascular / CVRM2
Neuroscience2
Vaccines & Infectious Disease1
Respiratory1
Gastroenterology1

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

100%similar
GlaxoSmithKline LLC Waltham, United States Director
Same function Same therapeutic area Same seniority Same country
100%similar
Amgen Inc. South San Francisco, United States Director
Same function Same therapeutic area Same seniority Same country
90%similar
Jazz Pharmaceuticals, Inc. Home-Based, United States Senior Director
Same function Same therapeutic area Adjacent seniority Same country
85%similar
Amgen Capability Center Portugal Ltda Director
Same function Same therapeutic area Same seniority

Open in 3 locations

Remote, PolandRemote, SpainLisbon, Portugal
75%similar
Roche Basel, Basel-City, Switzerland Principal
Same function Same therapeutic area Adjacent seniority
60%similar
Lilly Indianapolis, Indiana, United States of America Director
Same function Same seniority Same country

Notify me about similar jobs

Get an email when we spot other openings like this one – same job function, comparable seniority, roles you'd actually want to see.

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

100%
Director, AI/ML MIDD Oncology Clinical Pharmacology, Modeling and Simulation
GlaxoSmithKline LLC · Waltham, United States · Director
Function Therapeutic area Seniority Country
90%
Senior Director, Oncology Pharmacology
Jazz Pharmaceuticals, Inc. · Home-Based, United States · Senior Director
Function Therapeutic area Adjacent seniority Country
85%
Clinical Scientist Director, Early Development Oncology
Amgen Capability Center Portugal Ltda · Lisbon, Portugal · Director
Function Therapeutic area Seniority Country
60%
Director, Molecular Pharmacology
Lilly · Indianapolis, Indiana, United States of America · Director
Function Therapeutic area Seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.