AI & Intelligent Systems Enablement Manager

Use Your Power for Purpose

The AI & Intelligent Systems Enablement Manager serves as the site's trusted advisor on AI and digital maturity, identifying the organizational capabilities required to modernize how work gets done and to responsibly adopt emerging technologies.

This role leads the identification, design, and delivery of AI-enabled digital solutions that improve operational performance across the site. Working closely with business stakeholders, the Manager determines where digital decision-making, analytics, automation, or AI create meaningful, sustainable value, and builds it.

What You Will Achieve

In this role, you will:

AI Solution Development

Design and develop AI-enabled solutions that address approved business needs, including retrieval-augmented generation (RAG) solutions and generative AI use cases. Integrate AI into existing digital products where it measurably improves business value.

Data Readiness

Assess data availability and quality relevant to digital or AI applications. Work with data owners to close gaps needed for reliable AI outcomes.

Digital Process Improvement

Identify opportunities to simplify and digitize workflows. Support technology-enabled process improvements alongside CI Specialists and Improvers, and recommend and implement continuous-improvement initiatives.

Strategy & AI Readiness

Advise site leadership on AI-appropriate applications. Develop roadmaps that integrate emerging technologies into manufacturing operations, and recommend investments that strengthen AI and long-term digital performance.

Site Consultation & Project Intake

Partner with business functions to identify digital improvement needs. Guide project scoping, feasibility assessment, and technology selection, and ensure initiatives follow the site's standard project intake and governance process.

Site Enablement & Training

Deliver awareness sessions and training that build digital and AI capability across colleagues. Support upskilling initiatives aligned with the site's Digital Workforce framework.

AI Governance & Responsible Adoption

Ensure all solutions comply with corporate governance, security, validation, and responsible-AI requirements, including guardrails against hallucination and bias. Promote appropriate use of AI across the site and document governance decisions.

Technology Leadership

Monitor industry trends in emerging AI technologies and platform developments. Evaluate new tools for potential site adoption, share best practices with Digital Engineering and site leadership, and maintain awareness of evolving regulatory and governance expectations.

What Success Looks Like

Increased operational visibility through digital tools

Improved decision support through AI-powered guidance

Reduced manual effort through workflow digitization

Increased digital maturity site-wide

AI solutions delivered with measurable, tracked business value

Increased colleague digital and AI fluency

Here Is What You Need (Minimum Requirements)

Applicant must have a Bachelor’s degree in Computer Science, Data Science, Engineering, or a related field with at least 4 years of experience OR Master’s degree with more than 2 years of experience, OR a PhD with 0 years of experience OR High School Diploma (or Equivalent) and 10 years of relevant experience OR an Associate’s degree with 8 years of experience.

Experience in AI/ML solution development, data engineering, or digital solutions delivery

Hands-on experience with large language models and orchestration frameworks (e.g., LangChain, OpenAI APIs, or similar) for building agentic workflows

Experience designing tool-augmented agents, function calling, retrieval-augmented generation, memory systems, and planning/execution loops, rather than single-shot prompts

Working knowledge of vector databases, embeddings, and retrieval systems to support accurate, scalable knowledge retrieval

Experience applying prompt engineering, evaluation, and guardrail techniques (e.g., hallucination mitigation, output validation) to production-grade AI systems

Experience with low-code/no-code platforms such as Power BI and Power Automate

Demonstrated experience assessing data quality and readiness (completeness, accuracy, consistency, timeliness) for analytics or AI use cases

Proficiency in SQL or equivalent tools for querying and profiling data directly from source systems

Understanding of the differing data-quality requirements across AI approaches (e.g., retrieval-based, predictive, generative)

Familiarity with site operational systems (e.g., LIMS, SAP, EAMS, quality management systems)

Strong ability to translate technical capability into business value for non-technical stakeholders

Comfort operating across both strategic advisory work and hands-on technical delivery

Bonus Points If You Have (Preferred Requirements)

Experience in pharmaceutical, biotech, or other regulated manufacturing environments (GxP, CSV)

Exposure to AI governance or responsible-AI frameworks

Experience training or upskilling colleagues on new digital tools

Awareness of production AI system considerations such as latency, cost efficiency, and observability

Other job details

Last day to apply: September 18th, 2026

Work Location Assignment: Hybrid


The annual base salary for this position ranges from $99,200.00 to $165,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.



 Relocation assistance may be available based on business needs and/or eligibility.


 Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.


 Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.


 EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

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 To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on  Pfizer Careers .


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