Senior Scientist, Conjugation Process Development

Job Description

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

 

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be a member of our growing Conjugation Process Development team and will lead antibody-drug conjugate (ADC) process development projects ranging from early-phase clinical molecules through late-stage or commercial products. You will contribute to the development of ADC products targeting cancer to make a meaningful difference in people's lives. You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team.  Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

Role responsibilities

Independently design, execute, and interpret studies intended to answer a defined question within the defined timeframe. Design subsequent experiments upon interpretation of data.

Monitor results, identify problems, and develop solutions.

Facilitate technology/assay transfers internally/externally.

Regularly contribute at department and project team level and represent the group on multidisciplinary teams.

May present at national/international forums.

Author and review technical reports, manufacturing documents, regulatory submissions and publications.

Identify areas for process improvement and technology development and propose solutions

Qualifications

Must Have

Bachelor's Degree with 9 to11 years of experience, Master's Degree with 7 to 8 years of experience, or PhD and 0-3 years of experience

Degree in chemistry, biochemistry, chemical engineering, or related field

Direct experience with antibodies, proteins, and/or bioconjugation

Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)

Willingness to work with highly potent cytotoxic molecules

Ability to perform complex data analysis

Excellent oral and written communication skills

Foundational understanding of organic chemistry, reaction mechanisms, and process development

Nice to Have

Experience with tangential flow filtration

Experience using statistical and data analysis software, such as JMP, for experimental design, data visualization, and interpretation.

Experience with GMP manufacturing

Familiarity with CMC team function

Experience with technology transfer to manufacturing

Familiarity with chemical synthesis, protein modification, bioconjugation chemistry, and the application of analytical technologies to process development

 

Other Job Details

Work Location Assignment: On Premise


The annual base salary for this position ranges from $93,600.00 to $156,000.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.



 Relocation assistance may be available based on business needs and/or eligibility.


 Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.


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 EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

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Research and Development