Sanofi-Aventis Deutschland GmbH Posted August 6, 2026

HVAC Lead (all genders)

Frankfurt am Main, Germany Full time
Manufacturing & CMC

Sanofi-Aventis Deutschland GmbH is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

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position overview

The HVAC Lead – Clean Concept is the technical workstream leader responsible for the full design, engineering, procurement, construction, commissioning, and qualification of all HVAC systems and cleanroom environments within a major pharmaceutical capital project (€1 billion). This role ensures that all HVAC and clean concept solutions comply with GMP regulations, Sanofi global engineering standards, and HSE requirements, while meeting energy efficiency and carbon neutrality targets.

Main responsibilities:

Lead the HVAC & Cleanroom design workstream end-to-end, from feasibility through qualification (C&Q), covering all cleanroom classifications (ISO 5–8 / EU GMP Grade A–D) and defining the Clean Concept (room classification, pressure cascades, airlock design, contamination control strategy)

Ensure compliance with Sanofi global standards for cleanroom design, HVAC energy optimization, air flow/air change rates, and environmental barriers (RABS/isolators), while overseeing design of AHUs, HEPA filtration (H13+), pressurization, temperature/humidity control, and containment strategies

Coordinate technical delivery with EPC contractors and engineering firms, reviewing and approving HVAC specifications, P&IDs, datasheets, and FAT/SAT protocols, including HVAC automation (PLC/BMS) design

Drive system integration across process, utilities, instrumentation, and BIM teams to ensure seamless 3D integration of HVAC systems into the overall building model

Champion Energy & Sustainability goals by applying Carbon Neutral Design principles (optimized air recycling, energy-efficient equipment selection) and ensuring alignment with Sanofi's CO₂ reduction targets and zero fossil primary energy design where applicable

Own HSE & GMP compliance throughout the project lifecycle (Phase 0–8), including pharmaceutical dust emission management, occupational hygiene controls for APIs, and participation in Pre-Start HSE Reviews (PSSR)

Manage the HVAC workstream schedule, budget, and reporting, tracking contractor progress, managing scope changes, and presenting status updates to the Engineering Project Manager and Project Steering Committee

Oversee FAT/SAT testing for all HVAC equipment to ensure readiness for qualification and handover

Serve as the single point of contact for all HVAC/Clean Concept topics, liaising with Quality, HSE, Operations, Regulatory Affairs, and the site HSE Manager/Business Partner to validate design choices

About you

Education/Experience: advanced Engineering degree in HVAC, Mechanical, Chemical, Bioprocess Engineering or equivalent; relevant experience in HVAC engineering for pharmaceutical or biotech manufacturing facilities, preferably in a lead/workstream leader role on large capital projects (>€100M)

Soft and technical skills: Deep understanding of EU GMP Annex 1, ISO 14644, FDA cGMP, and Sanofi global engineering standards; experience with BIM/Revit MEP, AutoCAD, Primavera P6 or equivalent scheduling tools, BMS/SCADA systems advantageous

Languages: proficiency in English required; German and additional languages welcome

Pursue progress , discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com !

The salary range for this position is :€79.104,00 - €118.656,00 Final compensation will be determined based on demonstrated experience, skills, location, and other relevant factors. Employees may be eligible to participate in Company employee benefit programs.

Job details

Seniority
Not listed
Function
Manufacturing & CMC
Therapeutic area
Not listed
Location
Frankfurt am Main, Germany
Employment type
Full time

How this role compares

Computed from every other active Manufacturing & CMC role in our database, not just this employer's listings.

We currently track 1527 comparable Manufacturing & CMC roles across 125 biopharma companies.

1527Comparable roles tracked
1434Currently active
125Companies hiring similar roles
44Countries represented

Salary context

456 of 1527 peers report a salary range (USD, annualized)

Peers share this role's job function. This posting doesn't list a seniority level, so peers aren't narrowed by seniority either -- the range below may span more levels than usual.

This roleSubject Not listed on this posting
Lowest disclosed · Senior Scientist II – CMC Developmental Sciences · AbbVie $0/hr – $0/hr (≈ $0–$0/yr)
Peer group range $0 – $540,400 (median $140,000)

Where these roles are based

Top locations among the 1527 comparable roles

United States782
India104
Germany73
Singapore67
France64
Ireland54

+ 38 more countries

Seniority mix

705 of 1527 peers have a known seniority level

Senior251
Manager165
Principal79
Associate68
Director64
Associate Director44
Senior Director21
Intern/Fellow/Postdoc8
Executive/VP5

Therapeutic area mix

7 of 1527 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Vaccines & Infectious Disease6
Oncology1

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

40%similar
Roche Penzberg, Bavaria, Germany Senior
Same function Same country
40%similar
Sanofi-Aventis Deutschland GmbH Frankfurt am Main, Germany
Same function Same country
40%similar
Sanofi-Aventis Deutschland GmbH Frankfurt am Main, Germany
Same function Same country
40%similar
Cellzome GmbH Heidelberg, Germany
Same function Same country
40%similar
Madaus GmbH Troisdorf, Germany
Same function Same country
40%similar
Madaus GmbH Troisdorf, Germany
Same function Same country

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

40%
Senior Associate Proteins Bioanalytics with Mass Spectrometry Expertise (m/f/d
Roche · Penzberg, Bavaria, Germany · Senior
Function Therapeutic area Seniority Country
40%
Laboratory Scientist - Automation (Proteomics) (m/f/d)
Cellzome GmbH · Heidelberg, Germany · Seniority not listed
Function Therapeutic area Seniority Country
40%
Teamleiter (m/w/d) Pharma
Madaus GmbH · Troisdorf, Germany · Seniority not listed
Function Therapeutic area Seniority Country
40%
Operator Mechanic (m/w/d) / Mechatroniker in der Produktion (m/w/d)
SmithKline Beecham Pharma GmbH & Co KG · Dresden, Germany · Seniority not listed
Function Therapeutic area Seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.