Vertex Pharmaceuticals Inc (US) Posted August 24, 2026

Global Health Economics & Outcomes Research (HEOR) Associate Director (HYBRID)

5000, United States Full time
Medical Affairs Associate Director

Vertex Pharmaceuticals Inc (US) is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

Job Description

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes   Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Associate   Director will participate in the shaping and execution of HEOR strategies that optimize the value   proposition and supporting evidence of Vertex’s innovative renal pipeline asset,   povetacicept , a dual   inhibitor of the BAFF and APRIL pathways, currently in phase III.

This position reports to the Senior   Director Global HEOR, Kidney.

Key Duties and Responsibilities:

​ •   Leads others to execute complex HEOR evidence generation including, cost-effective   analysis and budget impact models, prospective and retrospective observational studies,   ITCs, meta-analyses and systematic reviews, patient reported outcomes measure   development and validation, and other research as needed to support the asset value

•   Gathers and synthesizes insights from Payers, KOLs and HEOR experts; stays current   with scientific and policy trends and best practices and applies strategic and content   expertise to strategy planning.

•   Applies best practices to provide key input to the design of Vertex observational research   studies

•   Collaborates with the medical communications teams on publication strategy and ensure   that dissemination of HEOR evidence is timely and has maximum impact

•   Partners and works closely with Global Pricing and Market Access to support production of   GVD and Value Narrative

Knowledge and Skills:

• Strong track record of publication in peer-reviewed journals

•   Provides technical expertise in HEOR and can formulate and lead creative research   projects and ensure conduct is technically and scientifically rigorous and reflects best   HEOR practices

•   Strong verbal and written communications skills, including presentation skills to   communicate difficult concepts and persuade others; comfortable communicating complex   concepts and adapting presentation style to a variety of audiences.

•   Ability to apply knowledge of US healthcare system, global health technology appraisal   requirements, and clinical development, to identify evidence gaps and formulate evidence   generation strategies.

•   Understanding of the legal and regulatory environment of the pharmaceutical industry, with   spotless history of compliance and ethical workplace conduct

Education and Experience:

• Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline.

•   Typically requires 8 years of experience, with substantial background in HEOR, or the   equivalent combination of education and experience

Pay Range:

$176,000 - $264,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

1.    Hybrid: work remotely up to two days per week; or select

2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Job details

Seniority
Associate Director
Function
Medical Affairs
Therapeutic area
Not listed
Location
5000, United States
Employment type
Full time

How this role compares

Computed from every other active Medical Affairs role in our database, not just this employer's listings.

We currently track 355 comparable Associate Director Medical Affairs roles across 92 biopharma companies.

355Comparable roles tracked
337Currently active
92Companies hiring similar roles
36Countries represented

Salary context

78 of 355 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject $176,000/yr – $264,000/yr
Lowest disclosed · Manager, Medical Operations · Merck KGaA $92,900/yr – $139,300/yr
Peer group range $116,100 – $322,000 (median $186,875)

Where these roles are based

Top locations among the 355 comparable roles

United States120
China31
Japan29
Germany25
China's Mainland19
India17

+ 30 more countries

Seniority mix

355 of 355 peers have a known seniority level

Manager160
Senior134
Associate Director61

Therapeutic area mix

120 of 355 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Oncology44
Immunology19
Rare Disease12
Dermatology & Aesthetics12
Neuroscience8
Cardiovascular / CVRM7
Gastroenterology7
Vaccines & Infectious Disease6
Respiratory4
Ophthalmology1

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The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

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Notify me about similar jobs

Get an email when we spot other openings like this one – same job function, comparable seniority, roles you'd actually want to see.

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

60%
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Function Therapeutic area Seniority Country
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Gilead Sciences, Inc. · Foster City, United States · Associate Director
Function Therapeutic area Seniority Country
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Associate Director, Health Economics & Outcomes Research, Solid Tumors
Regeneron Pharmaceuticals, Inc (USA) · Sleepy Hollow, United States · Associate Director
Function Therapeutic area Seniority Country
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Associate Director, Global Medical Cardiovascular, Mavacamten
E.R. Squibb & Sons,L.L.C. · Princeton, United States · Associate Director
Function Therapeutic area Seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.