Senior Medical Director, Radiopharmaceutical Imaging (RPI)

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact, on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

The Senior Medical Director, Radiopharmaceutical Imaging (RPI) provides strategic and operational leadership for the development of RayzeBio’s diagnostic imaging pipeline across disease areas, including but not limited to prostate cancer, hepatocellular cancer, and neuroendocrine tumors. This role is accountable for the imaging portfolio strategy, development plans, and key decision making from IND-enabling activities through Phase 0–Phase 3 clinical trials, including medical monitoring and benefit-risk assessments. The Senior Medical Director partners closely with cross-functional leaders (Clinical Development, Translational, Regulatory, Biomarkers, Safety, CMC, Biostatistics, Clinical Operations, Medical Affairs, and Commercial) to ensure integrated, high-quality execution, clear governance, and timely delivery of program milestones aligned with patient needs and RayzeBio’s business objectives.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

Define and own the diagnostic imaging portfolio strategy and target product profiles for nominated candidates, incorporating competitive intelligence and evolving standards of care.

Serve as imaging Clinical Development lead, providing medical and scientific direction across programs and ensuring robust, decision-oriented development plans.

Lead and influence cross-functional matrix teams and external partners (investigators, academic collaborators, CROs, central readers) to design and execute early- and late-phase imaging studies.

Accountable for protocol concepts and critical document content, including protocols, investigator brochures, SAP inputs, clinical study reports, and key regulatory and medical communications. Performsmedical monitoring and data review activities in support of clinical studies

Provide medical oversight for trial conduct, including eligibility/risk assessments, safety review, medical monitoring strategy, and escalation pathways in collaboration with Drug Safety/Pharmacovigilance.

Lead governance for imaging programs, including data review activities and Independent Data Monitoring Committees (IDMCs)/Data Monitoring Committees (DMCs) as applicable.

Translate findings from research, translational, and nonclinical studies into imaging development opportunities and decision points; synthesize evidence to drive go/no-go recommendations.

Drive strategic regulatory engagement as clinical lead for health authority interactions, including briefing package strategy, participation in meetings, and representation of clinical rationale.

Establish and maintain strong relationships with clinical investigators and key opinion leaders; represent RayzeBio externally at scientific meetings and advisory boards as needed.

Work closely with CROs and vendors in the execution of clinical trials for radiopharmaceutical imaging agents

Participate in health authority interactions, preparation of briefing books, HA requests for information and regulatory filings.

Partner with Medical Affairs and Commercial to develop the evidence-generation strategy and lifecycle plans for radiopharmaceutical imaging within the broader RayzeBio portfolio.

Contribute to resource planning, timeline and budget management, risk mitigation/contingency planning, and vendor oversight to ensure delivery against milestones.

Leverages AI to drive program, portfolio, or functional performance through prioritization and scaled adoption.

Willing to travel approximately 30% of the time. Evening and weekend work may be required.

Education and Experience

MD (or equivalent) with 8+ years of pharmaceutical/biotech and/or relevant academic clinical experience, including substantial experience in oncology diagnostic development and/or radiopharmaceutical imaging agent development through regulatory submissions

Demonstrated leadership in clinical development with increasing levels of responsibility, including leading cross-functional teams and driving strategy through key development decisions.

Experience across early- and late-phase protocol development and execution, including study start-up, oversight of conduct, analysis inputs, and reporting.

Proven experience working closely with investigative sites (PIs, sub-investigators, coordinators) and managing external vendors (e.g., CROs, imaging core labs).

Skills and Qualifications

Patient-focused with deep commitment to improving outcomes for people with cancer and passion for developing novel radiopharmaceuticals and imaging agents.

Strategic clinical development leader who can set direction, align stakeholders, and drive decisions in a fast-paced, high-accountability environment.

Demonstrated ability to lead through influence in a matrix organization; able to build alignment across functions and levels, including senior leadership.

Strong scientific judgment and benefit–risk mindset; able to interpret complex imaging and clinical data and translate insights into clear development recommendations.

Executive-level written and verbal communication skills, including compelling presentations and the ability to represent the program effectively with health authorities and external experts.

Experience across early- and late-phase protocol development and execution, including study start-up, oversight of conduct, analysis inputs, and reporting.

Strong understanding of radiopharmaceutical imaging agent development, central reading paradigms, imaging endpoints, and operational considerations for multicenter trials.

Proven experience working closely with investigative sites (PIs, sub-investigators, coordinators) and managing external vendors (e.g., CROs, imaging core labs).

Ability to function in a highly regulated environment and to adhere to RayzeBio guidelines and standard operating procedures (SOPs).

Solid understanding of GCP and ICH guidelines.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 20 pounds. Specific vision abilities required by this job include close vision and distance vision.

Work Environment

The noise level in the work environment is usually moderate.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Remote - United States - US: $241,768 - $292,966


The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

Health Coverage: Medical, pharmacy, dental, and vision care.

Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).

Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

​ Work-life benefits include:

Paid Time Off

US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)

Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays

Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: T he summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to  adastaffingsupport@bms.com . Visit  careers.bms.com/ eeo -accessibility  to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:  https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If you believe that the job posting is missing information required by local law or incorrect in any way, please contact BMS at TAEnablement@bms.com . Please provide the Job Title and Requisition number so we can review. Communications related to your application should not be sent to this email and you will not receive a response.

R1603020 : Senior Medical Director, Radiopharmaceutical Imaging (RPI)