Vertex Pharmaceuticals Inc (US) Posted June 17, 2026

Senior Director, Portfolio & Program Management

Boston, United States Full time
Senior Director

Vertex Pharmaceuticals Inc (US) is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

Job Description

General Summary:

The Senior Director, Portfolio & Program Management is a global role within the Program and Portfolio Management (PPM) organization. The incumbent is responsible for championing cross-functional project management excellence to programs across the drug development lifecycle (Research, Pre-clinical and Clinical Development, Registration and Commercialization). The incumbent is expected to lead the application of project management to identify opportunities, shape objectives and drive execution of global strategy for cross-functional drug development teams and portfolio operations initiatives. This role is a key leadership position within PPM, with accountability for the performance and end results of a department/area.

Key Duties and Responsibilities: Provide strategic and operational project leadership to one or more cross-functional teams, directing activities at all stages of the project lifecycle (initiation through closeout)

Drive communication cross-functionally and with senior leaders on integrated program planning topics including timelines, status, risks and issues

Proactively identify roadblocks and/or constraints impacting strategic imperatives or project execution and lead the team through scenario planning activities

Partner with governance forums, senior leaders and/or team lead(s) to align strategy, goals and milestones with corporate objectives

Propose innovative approaches, define process improvements and advise leaders on opportunities to optimize project results

Determine approach and stakeholders for cross-functional decision-making and issue resolution

Oversee completion of project team deliverables and contribute to content development, when appropriate

Establish project team operating norms and measure performance

Apply subject matter expertise to mentor subordinate managers and high level professionals

As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned high level professionals and subordinate managers

Knowledge and Skills: Broad and comprehensive understanding of project and portfolio management principles, options analysis, strategic planning, business case generation, finance and resource management

Leadership experience managing cross-functional teams with an ability to influence teams to prioritize activities and allocate resources to contribute to the development of operational strategy

Excellent written and oral communication skills, including well-developed presentation skills

Pharmaceutical drug discovery and development expertise across multiple disciplines

Organizational skills, an ability to manage multiple priorities

Strong collaboration skills to effectively interact with internal or external stakeholders at all levels in the organization

Advanced business management knowledge to assess the impact of project decisions on financial and corporate objectives

Education and Experience: Typically requires a Bachelor’s degree in Life Sciences or a relevant field

Typically requires 12 years of experience and 5 years of management experience, or the equivalent combination of education and experience

Pay Range:

$242,200 - $363,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

1.    Hybrid: work remotely up to two days per week; or select

2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Job details

Seniority
Senior Director
Function
Not listed
Therapeutic area
Not listed
Location
Boston, United States
Employment type
Full time

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