Senior Clinical PBPK Modeling Scientist
About this opportunity
The ideal candidate will have strong background in pharmacokinetics and translational modeling. You will participate in implementing innovative and quantitative approaches to advance clinical drug development. Developing, qualifying, and applying mechanistic PBPK models using in vitro, preclinical, clinical, and literature data to support clinical development decisions across therapy areas. In addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology (CPQP) as per your experience, interests, and expertise dictate.
Typical Accountabilities
Utilize physiologically-based pharmacokinetic (PBPK) and translational modeling tools to enable clinical PK projections for drug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questions
Collaborate with Drug Metabolism and Pharmacokinetic (DMPK) Scientists and Clinical Pharmacology scientists to generate these mechanistic models
Develop fit-for-purpose, qualified PBPK models suitable for internal decision-making and regulatory use, including support for submission documentation and health authority interactions. Communicate clearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions
Keep up to date with emerging literature, modeling science, and regulatory expectations
Education, Qualifications, Skills and Experience
Essential
PhD degree preferred or equivalent (M.Sc./Pharm.D.)
Experience using PBPK platforms such as Simcyp, GastroPlus, or PK-Sim, together with scripting in R and/or Python for data analysis, visualization, and workflow automation.
Familiarity with AI-enabled scientific workflows, such as literature mining, coding assistance, or document summarization in compliant research environments
Demonstrated broad PBPK expertise and experience exemplified by 1-4 Years of drug development experience, with emphasis on PBPK modelling
Good knowledge in pharmacokinetics, drug-drug interactions, regulatory guidance in clinical pharmacology, modelling and simulation sciences
Demonstrated ability to identify, develop and execute PBPK activities at a project level
Good oral and written communication skills
Good knowledge of global regulatory, compliance, processes, standards and issues specific to PBPK
with relevant experience required
Experience authoring or contributing to PBPK technical reports and regulatory documentation, including submission-ready analyses and responses to health authority queries.Fluency in spoken and written English language
Desirable
A reputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology
Experience in early and late-stage drug development
Date Posted
11-ago-2026
Closing Date
30-ago-2026
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
Job details
How this role compares
Computed from every other active Clinical Development role in our database, not just this employer's listings.
We currently track 186 comparable Senior Clinical Development roles across 34 biopharma companies.
Salary context
41 of 186 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 186 comparable roles
+ 17 more countries
Seniority mix
186 of 186 peers have a known seniority level
Therapeutic area mix
21 of 186 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.