Principal Systems Engineer – Clinical Computation Platform
About this opportunity
Career Category
Clinical
Job Description
ABOUT AMGEN
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We discover, develop, manufacture and deliver innovative medicines to help millions of patients. Amgen helped establish the biotechnology industry more than 40 years ago and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today.
ABOUT THE ROLE
Role Description:
The role is responsible for the design, integration, and management of complex systems that encompass both hardware and software components into the organization’s cloud infrastructure . Th is individual will be responsible for all activities related to handling and supporting the Business and platforms including system administration, as well as incorporating new technologies under the challenge of a sophisticated and constantly evolving technology landscape . This role involves ensuring that all parts of a system work together seamlessly to meet the organization’s requirements.
Roles & Responsibilities:
Collaborate with business partners and other software engineers to develop and deploy the latest, advanced technologies in support of product optimization
Work closely with the delivery and platform teams to ensure that the applications are aligned with standard city planning approved architectural and development guidelines
Support selected efforts to design, build, and develop rapid Proof-of-Concept (POC) automated solutions and services. Quickly and iteratively prove or disprove the concepts being considered
Develop and design systems architecture, ensuring that it meets both current and future needs of the organization
Integrate hardware and software components into a cohesive system that meets functional and performance requirements
Perform system testing and validation to ensure all components function correctly and efficiently
Optimize system performance and troubleshoot any issues that arise during system operation
Create and maintain comprehensive documentation of systems design, configurations, and procedures
Work closely with other engineers, IT staff, and project managers to ensure successful implementation of systems
Monitor and maintain systems to ensure they continue to operate effectively and efficiently
Implement automation tools and processes to improve the efficiency and reliability of the system
Conduct training and workshops for business teams to share best practices in the industry.
Basic Qualifications and Experience:
Master’s / Bachelor’s degree with 13 - 17 years of experience in Computer Science, IT or related field
Functional Skills:
Must-Have Skills :
Experience in cloud platforms including AWS
Experience with container technologies like Docker and Kubernetes
Hands-on experience with computerized systems including troubleshooting, reliability, and performance improvements
Experience with translating business requirements to technical requirements and recommend solutions for automation
Proficiency in programming languages including R, Python
Experience and strong knowledge of POSIT Tools and Se rvices
Strong understanding of software development methodologies, including Agile and Scrum
Good-to-Have Skills:
Experience with DevOps tools and practices
Strong understanding of systems engineering processes and methodologies
Experience with systems integration and validation
Knowledge of Clinical Development domain
Professional Certifications :
Scaled Agile Framework ( SAFe ) for Teams (preferred)
Soft Skills:
Excellent analytical and troubleshooting skills
Strong verbal and written communication skills
Ability to work effectively with global, virtual teams
High degree of initiative and self-motivation
Ability to manage multiple priorities successfully
Team-oriented, with a focus on achieving team goals
Strong presentation and public speaking skills
Shift Information:
This position requires you to work a later shift and may be assigned a second or third shift schedule. Candidates must be willing and able to work during evening or night shifts, as required based on business requirements.
EQUAL OPPORTUNITY STATEMENT
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
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Job details
How this role compares
Computed from every other active Information Technology role in our database, not just this employer's listings.
We currently track 367 comparable Principal Information Technology roles across 36 biopharma companies.
Salary context
46 of 367 peers report a salary range (USD, annualized)
Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.
Where these roles are based
Top locations among the 367 comparable roles
+ 14 more countries
Seniority mix
367 of 367 peers have a known seniority level
Therapeutic area mix
1 of 367 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden
Similar opportunities
The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.
How we calculate "similar"
No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.
Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.
0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.