Principal Scientist II - Pharmacology

#LI-Onsite Location: Cambridge, MAThis position is located in Cambridge, MA and does not have the ability to be located remotely. Please only apply if this area is accessible to you.Over 40 therapies in the clinic! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. This is a labhead-based position, where the ideal candidate is expected to lead efforts in the design and execution of in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to develop novel in vivo assays to interrogate key scientific questions and deliver high-value translationally relevant data that can inform clinical development. Qualified candidates will have extensive experience in a variety of molecular biology skills. A strong background and expertise in antibody drug conjugates is preferred. We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly matrixed work environment, and can effectively communicate within multidisciplinary project teams.

Responsibilities:Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalitiesDevelop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questionsManage associate-level scientistsCollaborate with cross-functional project teamsCritically analyze and present results within a multidisciplinary team environmentCareful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebookQualifications:PhD with 5-8 years of research experience as a postdoc or in the pharmaceutical/biotech industryDeep knowledge of antibody drug conjugatesExtensive experience working with CDX and PDX xenograft tumor models and/or syngeneic modelsExpertise in cell culture, PCR, ELISA, western blot, and flow cytometryStrong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Prism and ExcelNovartis Compensation and Benefit Summary: The salary for this position is expected to range between $126,000 and $234,000 per year.The final salary offered is determined based on factors like, but not limited to, relevant skills andexperience, and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.Your compensation will include a performance-based cash incentive and, depending on the level of therole, eligibility to be considered for annual equity awards.US-based eligible employees will receive a comprehensive benefits package that includes health, life anddisability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.