Roche Posted June 13, 2026

Principal Bioinformatics Software Engineer

Santa Clara, California, United States of America FULL_TIME
Biostatistics & Data Science Principal

Roche is the source of truth for this posting and owns the application process. We surface normalized context and market comparison you won't find on the original listing.

About this opportunity

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

Roche Sequencing is not only changing science, but we are changing lives. Our software teams are laying the groundwork for the future by developing powerful bioinformatics algorithms, data analysis tools, and software/systems infrastructures so researchers and clinicians can make better health decisions faster. The path to curing cancer lies in ones and zeros as we work with next-generation genomic sequencing, a new frontier.

Do you want to develop software products that scientists and others in the life sciences will use to diagnose, find treatments, and eventually beat diseases like cancer? Our team builds highly scalable, reliable software and secure systems for better diagnostics. Come join us!

The Opportunity

As a Bioinformatics Software Engineer, you will design and develop automated verification tests for the bioinformatics components and pipelines that are used in Roche Sequencing products. You will be part of the team developing cutting-edge, distributed, scale-out Next-Generation Sequencing data analysis software to ensure the highest possible software quality for gene sequencing research and disease diagnostics.

Work closely with research and algorithm experts, accelerating bioinformatics techniques using GPU hardware. Support software development lifecycle and Design Control process, working closely with team members to continuously improve quality and feature sets of the software products, based on technical design and requirements specificationsWork closely with team members to continuously improve the quality and feature sets of software products. This includes supporting the software development lifecycle and Design Control process, based on technical design and requirements specifications.

Who You Are

B.S. or M.S. or PhD in Computational Biology or Bioinformatics or Biomedical engineering or related field.

5+ years of experience in working with NGS data and bioinformatics pipeline verification.

Strong expertise in Python, including numerical computing and data science libraries.

Proficiency in AWS and Linux Shell environments

Experience designing, documenting and executing verification tests.

Be self-driven, detail oriented, analytical and proven ability to learn quickly.

Be a team player, customer focused with excellent interdisciplinary collaboration skills.

Preferred Qualifications

Proven expertise in Object-Oriented Programming (OOP) using C++, and practical experience utilizing GPU-accelerated C/C++ libraries.

Experience with CI/CD tools and concepts.

Software verification experience focusing on medical device software or regulated applications.

Relocation benefits are not available for this posting

The expected salary range for this position based on the primary location of California is $165,800 - $308,000 annual.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below.

Benefits

 

 

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .

Job details

Seniority
Principal
Function
Biostatistics & Data Science
Therapeutic area
Not listed
Location
Santa Clara, California, United States of America
Employment type
FULL_TIME

How this role compares

Computed from every other active Biostatistics & Data Science role in our database, not just this employer's listings.

We currently track 62 comparable Principal Biostatistics & Data Science roles across 15 biopharma companies.

62Comparable roles tracked
55Currently active
15Companies hiring similar roles
13Countries represented

Salary context

24 of 62 peers report a salary range (USD, annualized)

Peers share this role's job function and a matching or adjacent seniority level -- not necessarily the same therapeutic area or country.

This roleSubject Not listed on this posting
Lowest disclosed · Sr. Computational Statistician (R2 – R3) · Lilly $46,842/yr – $117,289/yr
Highest disclosed · Scientific Director, Clinical and Real World Evidence · AbbVie $211,000/yr – $400,500/yr
Peer group range $82,066 – $305,750 (median $181,875)

Where these roles are based

Top locations among the 62 comparable roles

United States36
India6
Japan4
United Kingdom4
Germany3
China2

+ 7 more countries

Seniority mix

62 of 62 peers have a known seniority level

Senior27
Principal24
Director11

Therapeutic area mix

4 of 62 peers have a known therapeutic area; the rest are genuinely unlabeled, not hidden

Oncology4

Similar opportunities

The closest matches from our peer group, ranked by how similar they are, not how well you'd qualify for them -- treat this as market context, not a guaranteed shortlist; a weak match is labeled as one below.

60%similar
Lilly Indianapolis, Indiana, United States of America Principal
Same function Same seniority Same country
60%similar
Merck Rahway, New Jersey, United States of America Principal
Same function Same seniority Same country
60%similar
Merck Rahway, New Jersey, United States of America Principal
Same function Same seniority Same country
60%similar
Merck North Wales, Pennsylvania, United States of America Principal
Same function Same seniority Same country
60%similar
AbbVie North Chicago, IL Principal
Same function Same seniority Same country
60%similar
ViiV Healthcare Company Durham Blackwell Street, United States Principal
Same function Same seniority Same country

How we calculate "similar"

No black box, no LLM guesswork: a deterministic score built from four normalized attributes. Here's this role's own peer group at different match levels, so you can see the mechanism, not just the result.

Every comparison starts from the same 100-point budget: 25 for working in the same function, 40 for the same therapeutic area, 20 for the same or adjacent seniority, 15 for the same country. A dimension we can't confirm on both sides contributes nothing, never a guess, never a free pass.

60%
Principal Computational Statistician
Lilly · Indianapolis, Indiana, United States of America · Principal
Function Therapeutic area Seniority Country
60%
Associate Principal Scientist, Statistical Programming
Merck · Rahway, New Jersey, United States of America · Principal
Function Therapeutic area Seniority Country
60%
Principal Statistical Programmer
ViiV Healthcare Company · Durham Blackwell Street, United States · Principal
Function Therapeutic area Seniority Country
60%
Principal Data Scientist, 340B Strategy & Analytics
AbbVie · Mettawa, IL · Principal
Function Therapeutic area Seniority Country
Unmatched or unknown dimensions score exactly the same: 0 points, never a partial guess. A role we know almost nothing about beyond its function bottoms out at 25%; it never inflates to 100% just because there's little to compare against. Seniority uses a defined ladder (Associate → Manager → Associate Director → Senior → Principal → Director → Senior Director → Executive/VP) so "Director" and "Senior Director" count as adjacent, but "Director" and "Executive/VP" do not.