Director, CMC Digital Operations and Strategic Portfolio Lead

The Role

Reporting to the Executive Director of Digital Operations and Strategic Portfolio Management, the Director, CMC Digital Operations and Strategic Portfolio Management will own and drive a defined portfolio of strategic digital initiatives across Moderna’s CMC Digital organization and TPM for cross-CMC initiatives. This role sits at the intersection of digital strategy, CMC innovation, and enterprise execution, translating business priorities into clear portfolio plans, operating rhythms, decision frameworks, and measurable outcomes. The Director will partner closely with Digital, CMC, Finance, Operations, and external partners to enable predictable delivery, manage cross-functional dependencies and risks, and ensure digital investments are sequenced, resourced, governed, and communicated effectively. This role requires a strong operator and influential leader who can connect strategy to execution, build trust with senior stakeholders, and drive operational excellence across complex, high-impact programs.

Here's What You’ll Do

Own and define the operational delivery of a defined CMC Digital portfolio, translating Digital and CMC priorities into clear 1–2 year outcomes, OKRs, roadmaps, and execution plans.

Lead planning and governance rhythms across the portfolio, including prioritization, dependency and risk reviews, steering forums, decision records, and executive-ready portfolio updates.

Partner with Digital, CMC, TPM, Finance, Operations, and external partners to ensure initiatives are defined, sequenced, resourced, measured, and aligned to business value.

Drive predictable delivery across cross-CMC digital initiatives by identifying systemic blockers, escalating issues with clear options, and ensuring durable follow-through.

Co-lead the design and continuous improvement of the portfolio operating model, including intake, prioritization, capacity planning, value tracking, documentation, and runbook standards.

Build and maintain executive-facing dashboards and portfolio narratives that connect strategy, risk, investment, delivery health, and business impact.

Act as a strategic liaison between Digital and senior CMC stakeholders, translating complex technical roadmaps and program interdependencies into clear value stories and decision points.

Lead cross-functional working groups and stakeholder engagement mechanisms that promote alignment, transparency, accountability, and best-practice sharing across teams.

Drive resource and capacity planning across internal teams and external partners; manage multi-vendor delivery models and optimize for cost, quality, speed, and risk.

Partner with Finance and Operations to track budgets, support investment trade-off discussions, and ensure portfolio delivery aligns with Moderna’s enterprise goals.

Embed security, privacy, compliance, and audit-ready practices into portfolio execution, partnering with appropriate teams to manage risk and evidence requirements.

Use data-driven KPIs and outcome metrics to monitor portfolio performance, identify improvement opportunities, and steer operational decisions.

Communicate clearly during change, incidents, and portfolio shifts, helping stakeholders understand priorities, trade-offs, risks, and expected outcomes.

Here’s What You’ll Need (Basic Qualifications)

BA/BS degree in Information Technology, Business Administration, Life Sciences, Engineering, or a related field.

12+ years of experience in digital operations, IT, technical program management, portfolio management, or digital strategy execution, preferably in a regulated life sciences or pharmaceutical environment.

Demonstrated experience owning complex, cross-functional digital programs or portfolios with multiple workstreams, distributed teams, senior stakeholders, and external partners.

Strong understanding of portfolio governance, prioritization, OKRs/KPIs, dependency management, risk management, executive reporting, and delivery operating rhythms.

Experience translating business strategy and value streams into actionable digital roadmaps, execution plans, and measurable outcomes.

Strong financial and operational management skills, including budgeting, cost tracking, capacity planning, and investment trade-off support.

Excellent communication and influence skills, with the ability to simplify complex technical and operational topics for senior leaders and cross-functional audiences.

Working knowledge of Agile practices, product operating models, software delivery lifecycle, and modern digital delivery methods.

Knowledge of digital transformation challenges and opportunities within pharmaceutical CMC, manufacturing, quality, supply chain, or related regulated environments.

Here’s What You’ll Bring to the Table (Preferred Qualifications)

Advanced degree (MA/MS/MBA) in Information Technology, Business Administration, Life Sciences, Engineering, or a related field.

Fluency with product operating models, value-stream planning, software delivery lifecycle, and digital portfolio management practices.

Experience building or improving portfolio operating models, governance mechanisms, executive dashboards, decision records, and delivery runbooks.

Strong analytical and strategic thinking skills, with the ability to use data, metrics, and business context to guide prioritization and investment decisions.

Proven ability to lead change management, stakeholder alignment, and adoption efforts in a fast-moving, matrixed environment.

Experience with data platforms, lab automation, AI/ML-enabled capabilities, manufacturing systems, or CMC digital transformation initiatives.

Pay & Benefits

At Moderna, we believe that when you feel your best, you can do your best work. That’s why our benefits and well-being resources are designed to support you, at work, at home, and everywhere in between.

Competitive healthcare, plus voluntary benefit programs to support your unique needs

A holistic approach to well-being, with access to fitness, mindfulness, and mental health support

Family planning benefits, including fertility, adoption, and surrogacy support

Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown

Savings and investments to help you plan for the future

Location-specific perks and extras

The salary range for this role is $167,000.00 - $300,700.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs.

The successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance.

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.

Our Working Model 

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact.

Moderna is a smoke-free, alcohol-free, and drug-free work environment.

Equal Opportunities

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.  Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Accommodations

We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com .

Export Control Notice
This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant’s ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role Moderna is unable to sponsor non-U.S. persons to apply for an export control license.
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